Joachim Lingner

Joachim Lingner (born 1962) is a Swiss molecular biologist. He holds the professorship for life sciences and leads the Lingner Lab[1]at the École Polytechnique Fédérale de Lausanne (EPFL).

Joachim Lingner
Joachim Lingner
Born1962 (age 58–59)
NationalitySwiss
OccupationCell biology
Board member of
Awards
  • Friedrich Miescher Prize
  • ERC Advanced Investigator Award
Academic background
Alma materUniversity of Basel
Academic work
DisciplineCell biology
InstitutionsÉcole Polytechnique Fédérale de Lausanne (EPFL)
Main interests
Websitehttps://www.epfl.ch/labs/lingner-lab/

Career

Lingner obtained his PhD from the Biozentrum of the University of Basel in 1992.[2] In 1993 he joined the Howard Hughes Medical Institute at University of Colorado at Boulder for postdoctoral studies under the supervision of Thomas Cech.[3] He then joined Swiss Institute for Experimental Cancer Research (ISREC) in Lausanne, Switzerland, first as a junior group leader in 1997 and became senior group leader in 2002. In 2005 he was appointed as associate professor at EPF Lausanne. Since 2009, Lingner is a full professor at EPF Lausanne.[4][5]

Research

The Lingner Lab studies of the structure, function and maintenance of telomeres, the nucleoprotein complexes at the ends of eukaryotic chromosomes that enable chromosome stability and that regulate cellular lifespan. They elucidated how telomere shortening is counteracted by the telomerase enzyme that renders cancer cells immortal.[6][7] The lab discovered that telomeres are transcribed into telomeric repeat containing RNA (TERRA),[8] which in turn regulates the telomeric chromatin structure and telomere maintenance by telomerase and homology directed repair.[9][10] Finally, they developed technologies to uncover the changes that occur in the telomeric proteome during aging and disease including cancer.[10][11][12]

Distinctions

Lingner obtained the Friedrich Miescher Prize (2002),[13] was elected as an EMBO member (2005),[14] and received an ERC advanced investigator award (2008),[15] and is a member of the Academia Europaea (2020).[16]

He serves as a member of the scientific advisory board in the Center of Integrative Genomics (CIG) of the University of Lausanne,[17] and has been a member of ERC starting grant review panel.[18]

Selected works
  • Feretzaki M, Pospisilova M, Valador Fernandes R, Lunardi T, Krejci L, Lingner J. Rad51-dependent recruitment of TERRA lncRNA to telomeres through R-loops. Nature, Article, in press.
  • Vančevska, Aleksandra; Ahmed, Wareed; Pfeiffer, Verena; Feretzaki, Marianna; Boulton, Simon J.; Lingner, Joachim (2020). "SMCHD 1 promotes ATM ‐dependent DNA damage signaling and repair of uncapped telomeres". The EMBO Journal. 39 (7): e102668. doi:10.15252/embj.2019102668. PMC 7110143. PMID 32080884.
  • Porro, Antonio; Feuerhahn, Sascha; Delafontaine, Julien; Riethman, Harold; Rougemont, Jacques; Lingner, Joachim (2014). "Functional characterization of the TERRA transcriptome at damaged telomeres". Nature Communications. 5: 5379. Bibcode:2014NatCo...5.5379P. doi:10.1038/ncomms6379. PMID 25359189.
  • Grolimund, Larissa; Aeby, Eric; Hamelin, Romain; Armand, Florence; Chiappe, Diego; Moniatte, Marc; Lingner, Joachim (2013). "A quantitative telomeric chromatin isolation protocol identifies different telomeric states". Nature Communications. 4: 2848. Bibcode:2013NatCo...4.2848G. doi:10.1038/ncomms3848. PMID 24270157.
  • Chen, Liuh-Yow; Redon, Sophie; Lingner, Joachim (2012). "The human CST complex is a terminator of telomerase activity". Nature. 488 (7412): 540–544. Bibcode:2012Natur.488..540C. doi:10.1038/nature11269. PMID 22763445. S2CID 4412583.
  • Azzalin, C. M.; Reichenbach, P.; Khoriauli, L.; Giulotto, E.; Lingner, J. (2007). "Telomeric Repeat Containing RNA and RNA Surveillance Factors at Mammalian Chromosome Ends". Science. 318 (5851): 798–801. Bibcode:2007Sci...318..798A. doi:10.1126/science.1147182. PMID 17916692. S2CID 20693275.
  • Ahmed, Wareed; Lingner, Joachim (2018). "PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase". Genes & Development. 32 (9–10): 658–669. doi:10.1101/gad.313460.118. PMC 6004070. PMID 29773556.
  • Teixeira, M.Teresa; Arneric, Milica; Sperisen, Peter; Lingner, Joachim (2004). "Telomere Length Homeostasis is Achieved via a Switch between Telomerase- Extendible and -Nonextendible States". Cell. 117 (3): 323–335. doi:10.1016/s0092-8674(04)00334-4. PMID 15109493. S2CID 18179591.

References
  1. "LINGNER LAB". www.epfl.ch. Retrieved 2020-09-02.
  2. Lingner, Joachim; Kellermann, Josef; Keller, Walter (1991-12-12). "Cloning and expression of the essential gene for poly(A) polymerase from S. cerevisiae". Nature. 354 (6353): 496–498. Bibcode:1991Natur.354..496L. doi:10.1038/354496a0. ISSN 0028-0836. PMID 1840648. S2CID 2713293.
  3. Lingner, J. (1997-04-25). "Reverse Transcriptase Motifs in the Catalytic Subunit of Telomerase". Science. 276 (5312): 561–567. doi:10.1126/science.276.5312.561. PMID 9110970.
  4. Teixeira, M.Teresa; Arneric, Milica; Sperisen, Peter; Lingner, Joachim (April 2004). "Telomere Length Homeostasis Is Achieved via a Switch between Telomerase- Extendible and -Nonextendible States". Cell. 117 (3): 323–335. doi:10.1016/S0092-8674(04)00334-4. PMID 15109493. S2CID 18179591.
  5. Chen, Liuh-Yow; Redon, Sophie; Lingner, Joachim (August 2012). "The human CST complex is a terminator of telomerase activity". Nature. 488 (7412): 540–544. Bibcode:2012Natur.488..540C. doi:10.1038/nature11269. ISSN 0028-0836. PMID 22763445. S2CID 4412583.
  6. Teixeira, M.Teresa; Arneric, Milica; Sperisen, Peter; Lingner, Joachim (2004-04-30). "Telomere Length Homeostasis Is Achieved via a Switch between Telomerase- Extendible and -Nonextendible States". Cell. 117 (3): 323–335. doi:10.1016/S0092-8674(04)00334-4. PMID 15109493. S2CID 18179591.
  7. Chen, Liuh-Yow; Redon, Sophie; Lingner, Joachim (2012-07-04). "The human CST complex is a terminator of telomerase activity". Nature. 488 (7412): 540–544. Bibcode:2012Natur.488..540C. doi:10.1038/nature11269. ISSN 0028-0836. PMID 22763445. S2CID 4412583.
  8. Azzalin, Claus M.; Lingner, Joachim (2007-08-30). "Damage control". Nature. 448 (7157): 1001–1002. doi:10.1038/4481001a. ISSN 1476-4687. PMID 17728746. S2CID 37239103.
  9. Porro, Antonio; Feuerhahn, Sascha; Lingner, Joachim (2014-02-27). "TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres". Cell Reports. 6 (4): 765–776. doi:10.1016/j.celrep.2014.01.022. PMID 24529708.
  10. Vančevska, Aleksandra; Ahmed, Wareed; Pfeiffer, Verena; Feretzaki, Marianna; Boulton, Simon J; Lingner, Joachim (2020-04-01). "SMCHD1 promotes ATM-dependent DNA damage signaling and repair of uncapped telomeres". The EMBO Journal. 39 (7): e102668. doi:10.15252/embj.2019102668. ISSN 0261-4189. PMC 7110143. PMID 32080884.
  11. Grolimund, Larissa; Aeby, Eric; Hamelin, Romain; Armand, Florence; Chiappe, Diego; Moniatte, Marc; Lingner, Joachim (2013-11-25). "A quantitative telomeric chromatin isolation protocol identifies different telomeric states". Nature Communications. 4 (1): 2848. Bibcode:2013NatCo...4.2848G. doi:10.1038/ncomms3848. ISSN 2041-1723. PMID 24270157.
  12. Ahmed, Wareed; Lingner, Joachim (2017-12-04). "Impact of oxidative stress on telomere biology". Differentiation. 99: 21–27. doi:10.1016/j.diff.2017.12.002. PMID 29274896.
  13. "Awards - Funding - LS²". www.ls2.ch. Retrieved 2020-09-02.
  14. Katja. "Find a Member". EMBO. Retrieved 2020-09-02.
  15. https://erc.europa.eu/sites/default/files/content/selection_panel/advanced_grant_2008.pdf
  16. "List all members by country".
  17. "Scientific Advisory Committee". www.unil.ch. Retrieved 2020-09-02.
  18. https://erc.europa.eu/sites/default/files/document/file/erc_2018_stg_panel_members.pdf
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