Jenny Graves

Jennifer Ann Marshall Graves AO FAA (born 24 November 1941) is an Australian geneticist. She is Distinguished Professor within the La Trobe Institute for Molecular Science, La Trobe University, Australia and Professor Emeritus of the Australian National University.[1]

Jenny Graves
AO FAA
Born (1941-11-24) 24 November 1941
Adelaide, South Australia
NationalityAustralian
Alma mater
OccupationGeneticist
EmployerLa Trobe University
Awards
Websitebiology.anu.edu.au/people/jennifer-graves

Early life and education

Graves was born in Adelaide, South Australia in 1941. She attended Highgate Primary School, then Presbyterian Girls' College (now Seymour College), both in Adelaide.[2]

She received her BSc from the University of Adelaide in 1964, and an MSc in 1967 for work on the epigenetic silencing of one X chromosome in female marsupials.[3] She then received a PhD in 1971 for her work on the control of DNA synthesis from the University of California, Berkeley.[2]

Career

In 1971, Graves returned to Australia to lecture in genetics at La Trobe University, where she then became Professor in 1991.[2] As a teacher, she champions the idea that every biology topic is united by evolution and endorses the maxim that “Nothing in biology makes sense except in the light of evolution".[3]

Graves has published numerous high-profile papers in her career and has made a seminal contribution to understanding the organization, evolution, function and conservation of the mammalian genome. To do this, she has utilised the genetic diversity of Australian animals (specifically the kangaroo, platypus, Tasmanian devils and dragons (lizards)). Her work had led to significant and influential new theories on the origin and evolution of the human sex chromosomes and sex determination, including the controversial prediction that the human Y chromosome is disappearing.[4] She also made the critical discovery that the epigenetic silencing of mammalian X chromosomes occurs by transcriptional inhibition, and that this is mediated by DNA methylation. In the mid-1980s, Graves became involved in international comparative gene mapping and sequencing projects, where she promoted the value of including distantly related species in comparative genomics analyses and initiated projects to sequence the genomes of Australian marsupials and the platypus. In 2001 she became head of the Comparative Genomics Research Unit and Director of the ARC Centre for Excellence in Kangaroo Genomics, based at the Research School of Biological Sciences at the Australian National University.[3] During this time she worked extensively with Associate Professor Janine Deakin.[5]

In 1999 Graves was elected as Fellow of the Australian Academy of Science. Since this time she has served first as Foreign Secretary, then as Education Secretary where she was responsible for the Academy's science education projects.[6][7] She is a 2006 L’Oreal-UNESCO Laureate, and has received many awards for her work, including the MacFarlane Burnet Medal for research in biology, and an Order of Australia.[8][9][2]

In 2011 Graves returned to Melbourne as Distinguished Professor at La Trobe University, but retains honorary positions at the Australian National University (Professor Emeritus), the University of Canberra (Thinker-in-Residence) and the University of Melbourne (Professorial Fellow).[3][6][7]

In 2017 she was awarded the Prime Minister's Prize for Science (Australia) for "her pioneering investigations of the genetics of sex".[10]

Sex Determination

Graves, in conjunction with her then PhD student Andrew Sinclair, was instrumental in providing evidence that the ZFY gene, at the time proposed to be the testis-determining factor, was not required for sex determination in mammals. Sex determination in placental mammals (including marsupials) results from a testis-determining gene on the Y chromosome. Via comparative genomics, Graves and Sinclair showed that ZFY is found on chromosome 5 in kangaroos and chromosome 3 in the fat-tailed dunnart rather than the Y chromosome, and therefore could not be involved in determining sex.[11][12] Sinclair later showed that SRY was in fact the gene responsible for sex determination in mammals.[13][12]

Following this, Graves discovered that the platypus sex chromosomes are homologous to the bird ZW rather than conserved with the mammalian XY. Owing to this work, the emergence of mammalian sex chromosomes could be dated back to between 160-190 million years ago, between the divergence of therian mammals from monotremes and the divergence of the marsupial-eutherian species.[12]

Graves' work on sex determination led to the discovery that the Australian reptile the dragon lizard exhibits both genetic and temperature dependent sex determination. At normal temperatures, the sex of offspring is determined via genetic factors (ZZ male, ZY female) as two copies of this Z-borne gene (ZZ) are required to induce testis formation. At higher temperatures, however, all hatchlings are female. It is proposed that this occurs due to heat inactivation of a dose sensitive Z-borne gene, resulting in ZZ hatchlings with insufficient sex determination product. Due to this reduced dose, ZZ hatchlings develop into sex-reversed females.[14][15] This work condradicted the prevailing hypothesis at the time that genetic and temperature dependent sex determining systems were fundamentally different.

Honours

References
  1. "Professor Jennifer Graves". ANU College of Medicine, Biology & Environment: Research School of Biology. Archived from the original on 2 February 2014. Retrieved 19 January 2014.
  2. "Interviews with Australian scientists - Professor Jenny Graves". Australian Academy of Science. Archived from the original on 29 October 2013. Retrieved 28 October 2013.
  3. "Staff profile, Science, Technology and Engineering, La Trobe University". 2014-02-22. Archived from the original on 2014-02-22. Retrieved 2019-07-29.
  4. Thursday, 23 February 2012 ABC/AFP (2012-02-23). "Many years of life left in Y chromosome". www.abc.net.au. Retrieved 2019-07-29.
  5. "Ms Janine Deakin - Researchers - ANU". 2014-08-19. Archived from the original on 2014-08-19. Retrieved 2019-07-29.
  6. Director (Research Services Division). "Emeritus Professor Jennifer Graves". researchers.anu.edu.au. Retrieved 2019-07-29.
  7. Holmes, David (2014-10-01). "Jenny Graves: the free spirit of scientific enquiry". The Lancet Diabetes & Endocrinology. 2 (10): 779. doi:10.1016/S2213-8587(14)70116-0. ISSN 2213-8587. PMID 25127484.
  8. "Macfarlane Burnet Medal and Lecture". Australian Academy of Science. Retrieved 22 February 2017.
  9. "Staff profile: Professor Jenny Marshall Graves AO, FAA". La Trobe University. Archived from the original on 22 February 2014. Retrieved 22 January 2014.
  10. "Scientist who predicts male sex chromosome is declining takes PM's prize". ABC News. 18 October 2017. Retrieved 18 October 2017.
  11. Sinclair, Andrew H.; Foster, Jamie W.; Spencer, James A.; Page, David C.; Palmer, Mark; Goodfellow, Peter N.; Graves, Jennifer A. Marshall (December 1988). "Sequences homologous to ZFY, a candidate human sex-determining gene, are autosomal in marsupials". Nature. 336 (6201): 780–783. Bibcode:1988Natur.336..780S. doi:10.1038/336780a0. ISSN 0028-0836. PMID 3144651. S2CID 4345322.
  12. Graves, Jennifer A. Marshall (2017-01-23). "How Australian mammals contributed to our understanding of sex determination and sex chromosomes". Australian Journal of Zoology. 64 (4): 267–276. doi:10.1071/ZO16054. ISSN 1446-5698.
  13. Gitschier, Jane (2008-06-27). "The Exception That Proves the Rule: An Interview with Jenny Graves". PLOS Genetics. 4 (6): e1000063. doi:10.1371/journal.pgen.1000063. ISSN 1553-7404. PMC 2377341. PMID 18584021.
  14. Graves, Jennifer A. Marshall (2008). "Weird Animal Genomes and the Evolution of Vertebrate Sex and Sex Chromosomes". Annual Review of Genetics. 42 (1): 565–586. doi:10.1146/annurev.genet.42.110807.091714. PMID 18983263.
  15. Ezaz, Tariq; Quinn, Alexander E.; Miura, Ikuo; Sarre, Stephen D.; Georges, Arthur; Marshall Graves, Jennifer A. (December 2005). "The dragon lizard Pogona vitticeps has ZZ/ZW micro-sex chromosomes". Chromosome Research. 13 (8): 763–776. doi:10.1007/s10577-005-1010-9. ISSN 0967-3849. PMID 16331408. S2CID 4934610.
  16. "GRAVES, Jennifer Marshall". Australian Honours Search Facility, Dept of Prime Minister & Cabinet. Retrieved 15 March 2018.
  17. "GRAVES, Jennifer Marshall". Australian Honours Search Facility, Dept of Prime Minister & Cabinet. Retrieved 15 March 2018.
  18. "2019 NAS Election". National Academy of Sciences. April 30, 2019.
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