Iva Tolić

Iva Marija Tolić (born 24 June 1974) is a Croatian biophysicist, known for her work on the microtubule cytoskeleton and associated motor proteins. She is currently Senior Research Group Leader and Professor of Biology at the Ruđer Bošković Institute in Zagreb, Croatia.[1]

Prof. dr. sc.

Iva Tolić
Iva Tolić, Ruđer Bošković Institute
Born (1974-06-24) June 24, 1974
Zagreb, Croatia
NationalityCroatian
OccupationScientist/Academic
Spouse(s)Nenad Brgić (married 2014)
Children2
AwardsLieben Prize (2017)
EBSA Young Investigators' Medal and Prize (2015)
Cell '40 under 40' (2014)
Academic background
EducationPhD
Alma materUniversity of Zagreb, Croatia
Thesis (2002)
Academic work
DisciplineBiology
Sub-disciplineBiophysics
InstitutionsMax Planck Institute of Molecular Cell Biology and Genetics (Dresden, Germany)
Ruđer Bošković Institute
(Zagreb, Croatia)
Websitehttp://tolic.irb.hr/

Education

Tolić completed her Diploma in Molecular Biology from the University of Zagreb, Croatia in 1996 and her Graduate Studies in Molecular Biology in the group of Prof. Nenad Trinajstić, Ruđer Bošković Institute and University of Zagreb, Croatia in 1999. Between 1999 and 2001, she completed part of her PhD work with Prof. Ning Wang, Harvard School of Public Health, Boston, United States and was awarded her doctorate in Biology in 2002 by the University of Zagreb, Croatia.[1]

Career

Upon obtaining her doctorate, Tolić did her first Post-doctoral training between 2001 and 2002 at the Niels Bohr Institute, Copenhagen, Denmark working with Prof. Lene Oddershede and Prof. Kirstine Berg-Sorensen on the microrheology of cells. She then joined the European Laboratory for Non-Linear Spectroscopy, Florence, Italy for post-doctoral research with Prof. Francesco Pavone, working on lymphocyte movement and laser microsurgery on the mitotic spindle. Following her Post-doctoral training, Tolić was appointed as Research Group Leader (W1, equivalent to Assistant Professor) at the Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany in 2005 and was promoted to Senior Research Group Leader (W2, equivalent to Associate Professor) in 2010. In 2014, she moved to the Ruđer Bošković Institute, Zagreb, Croatia, being appointed as Senior Research Group Leader and Professor of Biology.[2]

Research

As independent investigator, Tolić has carried out pioneering research in the field of cell biology pertaining to the microtubule cytoskeleton and associated motor proteins, discovering: (i) a novel mechanism of kinetochore capture during mitosis by pivoting of astral microtubules around the spindle pole,[3] (ii) a mechanism of regulation of the motor protein cytoplasmic dynein by attachment to its anchor protein in fission yeast[4] and most recently, (iii) 'Bridging fibers' that are non-kinetochore microtubules connecting sister k-fibers and thereby balancing forces in the spindle.[5]

In addition, her research has demonstrated that fission yeast does not undergo replicative aging, contrary to existing theories on aging.[6][7]

Personal life

Tolić's parents are the journalist and diplomat Benjamin Tolić and academic Dubravka Oraić-Tolić. She married Nenad Brgić in 2014 and she is the mother of two children. She has stated publicly that she sees no conflict between religion and science.[8]

Awards and Achievements

Membership in Professional Associations and Societies

Tolić is a member of European Molecular Biology Organization, the Croatian Biophysical Society, the Croatian Society of Biochemistry and Molecular Biology and the Croatian Microscopy Society. In addition, she is Member of the Scientific Advisory Board of the journal Science.

References
  1. RBI. "Iva Tolić / People / Ruđer Bošković Institute". www.irb.hr.
  2. "Archived copy". Archived from the original on 2016-08-19. Retrieved 2016-07-19.CS1 maint: archived copy as title (link)
  3. Kalinina, Iana; Nandi, Amitabha; Delivani, Petrina; Chacón, Mariola R.; Klemm, Anna H.; Ramunno-Johnson, Damien; Krull, Alexander; Lindner, Benjamin; Pavin, Nenad; Tolić-Nørrelykke, Iva M. (2012). "Pivoting of microtubules around the spindle pole accelerates kinetochore capture". Nature Cell Biology. 15 (1): 82–87. doi:10.1038/ncb2640. ISSN 1465-7392. PMID 23222841.
  4. Ananthanarayanan, Vaishnavi; Schattat, Martin; Vogel, Sven K.; Krull, Alexander; Pavin, Nenad; Tolić-Nørrelykke, Iva M. (2013). "Dynein Motion Switches from Diffusive to Directed upon Cortical Anchoring". Cell. 153 (7): 1526–1536. doi:10.1016/j.cell.2013.05.020. ISSN 0092-8674. PMID 23791180.
  5. Kajtez, Janko; Solomatina, Anastasia; Novak, Maja; Polak, Bruno; Vukušić, Kruno; Rüdiger, Jonas; Cojoc, Gheorghe; Milas, Ana; Šumanovac Šestak, Ivana; Risteski, Patrik; Tavano, Federica; Klemm, Anna H.; Roscioli, Emanuele; Welburn, Julie; Cimini, Daniela; Glunčić, Matko; Pavin, Nenad; Tolić, Iva M. (2016). "Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores". Nature Communications. 7: 10298. doi:10.1038/ncomms10298. ISSN 2041-1723. PMC 4728446. PMID 26728792.
  6. Coelho, Miguel; Dereli, Aygül; Haese, Anett; Kühn, Sebastian; Malinovska, Liliana; DeSantis, Morgan E.; Shorter, James; Alberti, Simon; Gross, Thilo; Tolić-Nørrelykke, Iva M. (2013). "Fission Yeast Does Not Age under Favorable Conditions, but Does So after Stress". Current Biology. 23 (19): 1844–1852. doi:10.1016/j.cub.2013.07.084. ISSN 0960-9822. PMC 4620659. PMID 24035542.
  7. Coelho, Miguel; Lade, Steven J.; Alberti, Simon; Gross, Thilo; Tolić, Iva M. (2014). "Fusion of Protein Aggregates Facilitates Asymmetric Damage Segregation". PLoS Biology. 12 (6): e1001886. doi:10.1371/journal.pbio.1001886. ISSN 1545-7885. PMC 4061010. PMID 24936793.
  8. S, Veronika. "Prof. dr. Iva Tolić, hrvatska znanstvenica uvrštena među 40 najboljih u svijetu". Kamenjar. Retrieved 31 December 2017.
  9. "Archived copy". Archived from the original on 2016-08-15. Retrieved 2016-07-19.CS1 maint: archived copy as title (link)
  10. "Prizes and medals awarded by EBSA - European Biophysical Societies' Association". ebsa.org.
  11. "Archived copy". Archived from the original on 2016-08-16. Retrieved 2016-07-19.CS1 maint: archived copy as title (link)
  12. "Investigator of the Year". mpi-cbg.de.
  13. "Iva Tolic-Norrelykke: Cell Press". www.cell.com.
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