Interolog

An interolog is a conserved interaction between a pair of proteins which have interacting homologs in another organism. The term was introduced in a 2000 paper by Walhout et al.[1][2]

Example

Suppose that A and B are two different interacting human proteins, and A' and B' are two different interacting dog proteins. Then the interaction between A and B is an interolog of the interaction between A' and B' if the following conditions all hold:

  • A is a homolog of A'. (Protein homologs have similar amino acid sequences and derive from a common ancestral sequence).
  • B is a homolog of B'.
  • A and B interact.
  • A' and B' interact.

Thus, interologs are homologous pairs of protein interactions across different organisms.

See also

References
  1. Walhout, A. J.; Sordella, R.; Lu, X.; Hartley, J. L.; Temple, G. F.; Brasch, M. A.; Thierry-Mieg, N.; Vidal, M. (2000). "Protein Interaction Mapping in C. Elegans Using Proteins Involved in Vulval Development". Science. 287 (5450): 116–122. Bibcode:2000Sci...287..116W. doi:10.1126/science.287.5450.116. PMID 10615043.
  2. Yu, H.; Luscombe, N. M.; Lu, H. X.; Zhu, X.; Xia, Y.; Han, J. D.; Bertin, N.; Chung, S.; Vidal, M.; Gerstein, M. (2004). "Annotation Transfer Between Genomes: Protein-Protein Interologs and Protein-DNA Regulogs". Genome Research. 14 (6): 1107–1118. doi:10.1101/gr.1774904. PMC 419789. PMID 15173116.


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