Inositol 1-methyltransferase
In enzymology, an inositol 1-methyltransferase (EC 2.1.1.40) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + myo-inositol S-adenosyl-L-homocysteine + 1D-1-O-methyl-myo-inositol
| inositol 1-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.40 | ||||||||
| CAS number | 37257-06-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are S-adenosyl methionine and myo-inositol, whereas its two products are S-adenosylhomocysteine and 1D-1-O-methyl-myo-inositol.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:1D-myo-inositol 1-O-methyltransferase. Other names in common use include inositol D-1-methyltransferase, S-adenosylmethionine:myo-inositol 3-methyltransferase, myo-inositol 3-O-methyltransferase, inositol 3-O-methyltransferase (name based on 1L-numbering system, and not 1D-numbering), and S-adenosyl-L-methionine:myo-inositol 3-O-methyltransferase. This enzyme participates in inositol phosphate metabolism.
References
- Wagner I, Hofmann H, Hoffmann-Ostenhof O (1969). "[Biosynthesis of cyclitols. 23. A soluble enzyme from pea seedlings methylating myo-inositol to D-bornesitol]". Hoppe-Seyler's Z. Physiol. Chem. 350 (11): 1460–4. PMID 5362620.