Indolepyruvate decarboxylase
In enzymology, an indolepyruvate decarboxylase (EC 4.1.1.74) is an enzyme that catalyzes the chemical reaction
- 3-(indol-3-yl)pyruvate 2-(indol-3-yl)acetaldehyde + CO2
| indolepyruvate decarboxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.1.1.74 | ||||||||
| CAS number | 9074-92-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Hence, this enzyme has one substrate, 3-(indol-3-yl)pyruvate, and two products, 2-(indol-3-yl)acetaldehyde and CO2.
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]. Other names in common use include indol-3-yl-pyruvate carboxy-lyase, and 3-(indol-3-yl)pyruvate carboxy-lyase. This enzyme participates in tryptophan metabolism.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1OVM.
References
- Koga J (May 1995). "Structure and function of indolepyruvate decarboxylase, a key enzyme in indole-3-acetic acid biosynthesis". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1249 (1): 1–13. doi:10.1016/0167-4838(95)00011-I. PMID 7766676.
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