IPO4

Importin-4 is a protein that in humans is encoded by the IPO4 gene.[5][6]

IPO4
Identifiers
Aliases	IPO4, Imp4, importin 4
External IDs	MGI: 1923001 HomoloGene: 5835 GeneCards: IPO4
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 24,180,219 bp[1] End 24,188,869 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 C3|14 28.19 cM Start 55,625,400 bp[2] End 55,635,957 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • nuclear localization sequence binding • Ran GTPase binding Cellular component • cytoplasm • nuclear chromatin • not the membrane • nuclear pore • membrane • nuclear periphery • cell nucleus • macromolecular complex Biological process • protein transport • DNA replication-dependent nucleosome assembly • DNA replication-independent nucleosome assembly • intracellular protein transport • ribosomal protein import into nucleus • NLS-bearing protein import into nucleus • transport • protein import into nucleus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79711	75751
Ensembl	ENSG00000196497 ENSG00000285248	ENSMUSG00000002319
UniProt	Q8TEX9	Q8VI75
RefSeq (mRNA)	NM_024658	NM_024267 NM_001360078
RefSeq (protein)	NP_078934	NP_077229 NP_001347007
Location (UCSC)	Chr 14: 24.18 – 24.19 Mb	Chr 14: 55.63 – 55.64 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. ENSG00000285248 GRCh38: Ensembl release 89: ENSG00000196497, ENSG00000285248 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002319 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jakel S, Mingot JM, Schwarzmaier P, Hartmann E, Gorlich D (Feb 2002). "Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains". EMBO J. 21 (3): 377–86. doi:10.1093/emboj/21.3.377. PMC 125346. PMID 11823430.
6. "Entrez Gene: IPO4 importin 4".

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Miyauchi Y, Michigami T, Sakaguchi N, et al. (2006). "Importin 4 is responsible for ligand-independent nuclear translocation of vitamin D receptor". J. Biol. Chem. 280 (49): 40901–8. doi:10.1074/jbc.M509347200. PMID 16207705.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lischka P, Sorg G, Kann M, et al. (2003). "A Nonconventional Nuclear Localization Signal within the UL84 Protein of Human Cytomegalovirus Mediates Nuclear Import via the Importin α/β Pathway". J. Virol. 77 (6): 3734–48. doi:10.1128/JVI.77.6.3734-3748.2003. PMC 149505. PMID 12610148.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.