IFT74

Intraflagellar transport protein 74 homolog (IFT74), also known as coiled-coil domain-containing protein 2 (CCDC2) and capillary morphogenesis gene 1 protein (CMG1), is a protein that in humans is encoded by the IFT74 gene.[5][6]

IFT74
Identifiers
Aliases	IFT74, CCDC2, CMG-1, CMG1, intraflagellar transport 74, BBS20
External IDs	OMIM: 608040 MGI: 1914944 HomoloGene: 11831 GeneCards: IFT74
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p21.2 Start 26,947,039 bp[1] End 27,062,930 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C5 Start 94,614,491 bp[2] End 94,693,229 bp[2]
Gene ontology Molecular function • chromatin binding • beta-tubulin binding • GO:0001948 protein binding Cellular component • intraciliary transport particle B • centrosome • cell projection • ciliary tip • motile cilium • cytoplasmic vesicle • cell nucleus • cilium Biological process • Notch signaling pathway • intraciliary transport • heart development • keratinocyte development • determination of left/right symmetry • cell projection organization • epidermis development • negative regulation of epithelial cell proliferation • positive regulation of cell adhesion mediated by integrin • positive regulation of transcription from RNA polymerase II promoter • intraciliary transport involved in cilium assembly • cilium morphogenesis • non-motile cilium assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80173	67694
Ensembl	ENSG00000096872	ENSMUSG00000028576
UniProt	Q96LB3	Q8BKE9
RefSeq (mRNA)	NM_001099222 NM_001099223 NM_001099224 NM_025103 NM_001349928	NM_001290568 NM_026319
RefSeq (protein)	NP_001092692 NP_001092693 NP_001092694 NP_079379 NP_001336857	NP_001277497 NP_080595
Location (UCSC)	Chr 9: 26.95 – 27.06 Mb	Chr 4: 94.61 – 94.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

BCMG1 is upregulated by umbilical vein endothelial cells during capillary morphogenesis.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000096872 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028576 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: intraflagellar transport 74 homolog (Chlamydomonas)".
6. Bell SE, Mavila A, Salazar R, Bayless KJ, Kanagala S, Maxwell SA, Davis GE (August 2001). "Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling". J. Cell Sci. 114 (Pt 15): 2755–73. PMID 11683410.

Further reading

• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Xiao S, Sato C, Kawarai T, et al. (2008). "Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis". Neurobiol. Aging. 29 (8): 1279–82. doi:10.1016/j.neurobiolaging.2007.02.022. PMID 17383054. S2CID 10392826.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.