Holin superfamily VI

The Holin superfamily VI is a superfamily of integral membrane transport proteins. It is one of the seven different holin superfamilies in total. In general, these proteins are thought to play a role in regulated cell death, although functionality varies between families and individual members.

The Holin superfamily VI includes two TC families:[1]

Superfamily VI includes families with members only from Firmicutes. These proteins appear to have one N-terminal transmembrane segment (TMS), followed by an amphipathic, weakly hydrophobic peak that was not predicted to be transmembrane by the topological programs used by Reddy and Saier (2013).[2] The average sizes of the members of the two families belonging to the Holin superfamily VI are 135 ± 11 and 130 ± 26 amino acyl residues (aas), respectively.[2]

See also

References
  1. "Holin Superfamily VI". Transporter Classification Database. Retrieved 2016-03-20.
  2. Reddy, Bhaskara L.; Saier Jr., Milton H. (2013-11-01). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828 (11): 2654–2671. doi:10.1016/j.bbamem.2013.07.004. PMC 3788059. PMID 23856191.


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