Holin superfamily I

The Holin Superfamily I (aka the CDD phage holin1 superfamily) is a superfamily of integral membrane transport proteins. It is one of the seven different holin superfamilies in total. In general, these proteins are thought to play a role in regulated cell death, although functionality varies between families and individual members.

Its main constituent is the Phi11 Holin (φ11 Holin) Family.[1] This family is made up of over 270 putative pore-forming proteins, all from Firmicutes. On average, proteins belonging to the holin I superfamily are about 100 amino acyl residues (aas) in length, although a large size variation exists among proteins of this superfamily. There does not seem to be deviation from the standard two transmembrane segments that these proteins possess.[2][3]

See also

References
  1. "TC 1.E.11". tcdb.org. Transporter Classification Database.
  2. Reddy, Bhaskara L.; Saier Jr., Milton H. (2013-11-01). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828 (11): 2654–2671. doi:10.1016/j.bbamem.2013.07.004. PMC 3788059. PMID 23856191.
  3. "TCDB » Superfamilies". www.tcdb.org. Retrieved 2016-03-10.


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