Harvey Cantor

Harvey Cantor is an American immunologist known for his studies of the development and immunological function of T lymphocytes.[1][2] Cantor is currently the Baruj Benacerraf Professor of Microbiology & Immunobiology at the Harvard Medical School.[3]

Harvey Cantor
Harvey Cantor
Alma materColumbia University
NYU School of Medicine
Known forT cell subsets
Scientific career
FieldsImmunology
InstitutionsHarvard Medical School
Dana–Farber Cancer Institute

Research

Cantor's early studies focused on the development and function of lymphocytes derived from the thymus (T-lymphocytes or T cells).[4] In particular, his research addressed whether the multiple immunological functions of T cells were invested in a single lineage or represented the specialized activities of distinct T cell subsets.[5][6][7][8][9] This approach depended on the use of antibodies to cell surface glycoproteins or “markers” that might identify specialized subsets of lymphocytes with particular immunologic functions.[10] This experimental approach was also used to investigate other lymphocyte populations, including “natural killer” cells.[11] His laboratory continues to investigate the molecular and cellular elements that regulate the immune response and maintain self-tolerance.[12][13][14][15][16][17][18][19][20]

Education

Cantor received an A.B. from Columbia University and M.D. from New York University School of Medicine, followed by fellowship training at the National Institutes of Health (NIH) in Bethesda, MD with Richard Asofsky and as an NIH Special Fellow at the National Institute for Medical Research in Mill Hill, London. Following a residency in medicine at Stanford, he joined the faculty of Harvard Medical School in 1974 as an assistant professor of medicine and, since 1979, has been professor of pathology. In 1998, Cantor was appointed chair of the Department of Cancer Immunology & AIDS at the Dana-Farber Cancer Institute and in 2007 he was honored by appointment to the Baruj Benacerraf Professorship at Harvard Medical School.

Awards

Cantor was elected to the National Academy of Sciences (2002), the American Association for the Advancement of Science (2005) and the American Academy of Arts & Sciences (2010).[21]

References
  1. National Academy of Sciences |http://www.nasonline.org/member-directory/members/20002178.html
  2. Cooke, Robert (November 9, 1982). "Research points way to control of immune system". The Boston Globe.
  3. "Harvard Medical School Directory". Retrieved April 16, 2013.
  4. Foreman, Judy (April 25, 1997). "Cancer researcher receives $5m award". The Boston Globe.
  5. Cantor H, Boyse EA. Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen. J. Exp. Med. 1975;141:1376.
  6. Cantor H, Boyse EA. Functional subclasses of T-lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity. J. Exp. Med. 1975;141:1390.
  7. Huber B, Cantor H, Shen F-W, Boyse EA. Independent differentiative pathways of Ly1 and Ly23 subclasses of T-cells. Experimental production of mice deprived of selected T-cell subclasses. J. Exp. Med. 1976;144:1128.
  8. Nabel G, Fresno M, Chessman A, Cantor H. Use of cloned populations of mouse lymphocytes to analyze cellular differentiation. Cell 1981;23:19.
  9. Rao A, Allard WJ, Hogan PG, Rosenson RS, Cantor, H. Alloreactive T cell clones. Ly phenotypes predict both function and specificity for major histocompatibility complex products. Immunogenetics 1983;17:147.
  10. Boyse EA, Old LJ, Stockert E. An approach to the mapping of antigens on the cell surface. Proc Natl Acad Sci USA 1968;60:886.
  11. Glimcher L, Shen F-W, Cantor H. Identification of a cell-surface antigen selectively expressed on the natural killer cell. J. Exp. Med. 1977;145:1.
  12. Dickman, Steven (February 27, 1998). "Viral saboteurs caught in the act". Science.
  13. Leavy, Olive (October 2010). "CD8+ Treg cells join the fold". Nature Reviews Immunology. 10 (10): 680. doi:10.1038/nri2862. PMID 20879168.
  14. †Hu D, †Ikizawa K, Lu L, Sanchirico ME, Shinohara ML, Cantor H. Analysis of regulatory CD8 cells in mice deficient in the Qa-1 class Ib molecule. Nature Immunology, 2004;5:516
  15. Lu L, Ikizawa K, Hu D, Werneck MBF, Wucherpfennig KW, Cantor H. Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity, 2007;26: 593
  16. †Leavenworth JW, †Schellack C, †Kim H-J, Lu L, Spee P, and Cantor H. Analysis of the cellular mechanism underlying inhibition of EAE after treatment with anti-NKG2A F(ab)′2. Proc Natl Acad Sci USA, 2010;107:2562
  17. Kim H-J, Verbinnen B, Tang X, Lu L and Cantor H. 2010. Inhibition of follicular T helper cells by CD8+ Treg is essential for self tolerance. Nature 2010;467:328
  18. Kim, H-J, Wang X, Radfar S, Sproule TJ, Roopenian DC, Cantor H. CD8+ T regulatory cells express the Ly49 class I MHC receptor and are defective in autoimmune prone B6-Yaa mice. Proc Natl Acad Sci USA 2011;108:2010
  19. †Leavenworth JW, †Wang X, Wenander CS, Spee P, Cantor H. Mobilization of natural killer cells inhibits development of collagen-induced arthritis. Proc Natl Acad Sci USA 2011;108:14584
  20. Leavenworth JW, Tang X, Kim HJ, Wang X, Cantor H. Amelioration of arthritis through mobilization of CD8+ regulatory T cells. J Clin Invest, 2013;123:1382-9
  21. Lempinen, edited by Edward W. (October 28, 2005). "AAAS News and Notes". Science.CS1 maint: extra text: authors list (link)

Published papers
  • Huber B, Devinsky O, Gershon RK, Cantor H. Cell-mediated immunity: Delayed hypersensitivity and cytotoxic responses are mediated by different T-cell subclasses. J Exp Med 143: 1534–39.
  • Glimcher L, Shen FW, Cantor H. Identification of a cell-surface antigen selectively expressed on the natural killer cell. J Exp Med 145: 1–9.
  • Rao A, Ko WW, Faas SJ, Cantor H. Binding of antigen in the absence of histocompatibility proteins by arsonate-reactive T cell clones. Cell 36:879-888.
  • Rao A, Faas S and H. Cantor. Analogues which compete for antigen binding to an arsonate-reactive T cell clone inhibit the functional response to arsonate. Cell 36:889-95.
  • Patarca R, Freeman GJ, Singh RP, Wei FW, Durfee T, Blattner F, Regnier DC, Kozak CA, Mock BA, Morse III CA, Jerrells TR, Cantor H. Structural and functional studies of the Eta-1 (Early-T-lymphocyte-activation-1; Osteopontin) gene: Definition of a novel T-cell dependent response associated with genetic resistance to bacterial infection. J Exp Med 170:145-161.
  • Avery AC, Zhao ZS, Rodriquez A, Bikoff EK, Soheilian M, Foster CS, Cantor H.. Resistance to herpes stromal keratitis conferred by an IgG2a-derived peptide. Nature 376: 431–434.
  • Weber GF, Ashkar S, Glimcher MJ, Cantor H. Receptor-ligand interaction between Osteopontin (Eta-1) and CD44. Science 271: 509–512.
  • Zhao ZS, Granucci F, Yeh L, Schaffer PA, Cantor H. Molecular mimicry by herpes simplex virus-1: Autoimmune disease after viral infection. Science 279: 1344–1347.
  • Pestano GA, Zhou Y, Trimble LA, Daley J, Weber GF, Cantor H. Inactivation of mis-selected CD8 T cells by CD8 gene methylation and cell death. Science 284: 1187–1191.
  • Ashkar S, Weber GF, Panoutsakopoulou V, Sanchirico ME, Jansson M, Zawaideh S, Rittling SR, Denhardt DT, Glimcher MJ, Cantor H. Eta-1 (Osteopontin): an early component of type 1 (cell-mediated) immunity. Science 287: 860–864.
  • †Panoutsakopoulou V, †Sanchirico ME, Huster KM, Jansson M, Granucci F, Shim DJ, Wucherpfennig KW, Cantor H. Analysis of the relationship between viral infection and autoimmune disease. Immunity 15:137-147.
  • McCarty N, Paust S, Ikizawa K, Dan I, Li X, Cantor H. Signaling by MINK plays an essential role in negative selection of autoreactive thymocytes. Nature Immunology 6:65-72.
  • Shinohara ML, Lu L, Bu J, Werneck MBF, Kobayashi KS, Glimcher LH, Cantor H. Osteopontin expression is essential for IFN-γ production by plasmacytoid dendritic cells. Nature Immunology 7, 498–506.
  • Shinohara ML, Kim J-H, Garcia VA, Cantor H. Engagement of the Type I interferon receptor on dendritic cells inhibits promotion of Th17 cells: central role of intracellular Osteopontin. Immunity 29: 68–78.

† equal contributors

  • Dana-Farber Cancer Institute profile
  • Dana-Farber/Harvard Cancer Center (DF/HCC) profile
  • Harvard Medical School Program in Immunology profile
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