HS3ST2

Heparan sulfate glucosamine 3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the HS3ST2 gene.[5][6]

HS3ST2
Identifiers
AliasesHS3ST2, 30ST2, 3OST2, heparan sulfate-glucosamine 3-sulfotransferase 2
External IDsOMIM: 604056 MGI: 1333802 HomoloGene: 21220 GeneCards: HS3ST2
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16p12.2Start22,814,162 bp[1]
End22,916,338 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9956

195646

Ensembl

ENSG00000122254

ENSMUSG00000046321

UniProt

Q9Y278

Q673U1

RefSeq (mRNA)

NM_006043

NM_001081327
NM_177575

RefSeq (protein)

NP_006034

NP_001074796

Location (UCSC)Chr 16: 22.81 – 22.92 MbChr 7: 121.39 – 121.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system.[6]

Role in breast cancer The HS3ST2 promoter is hypermethylated in breast cancer tissue compared to normal breast ducts, suggesting a potential involvement in the pathogenesis of the disease.[7] Functional analysis revealed that upregulation of HS3ST2 in human breast cancer cells resulted in altered invasiveness, which was due to changes in Mitogen-activated protein kinase signaling and matrix metalloproteinase expression.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000122254 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000046321 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD (Mar 1999). "Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci". J Biol Chem. 274 (8): 5170–84. doi:10.1074/jbc.274.8.5170. PMID 9988767.
  6. "Entrez Gene: HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2".
  7. Dietrich, Dimo (2009). "Analysis of DNA Methylation of Multiple Genes in Microdissected Cells From Formalin-fixed and Paraffin-embedded Tissues". Journal of Histochemistry and Cytochemistry. 57 (5): 477–489. doi:10.1369/jhc.2009.953026. PMC 2674771. PMID 19153192.
  8. Vijaya Kumar, Archana (2014). "HS3ST2 modulates breast cancer cell invasiveness via MAP kinase- and Tcf4 (Tcf7l2)-dependent regulation of protease and cadherin expression". International Journal of Cancer. 135 (11): 2579–92. doi:10.1002/ijc.28921. PMID 24752740. S2CID 205950148.

Further reading


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