HNRNPLL

Heterogeneous nuclear ribonucleoprotein L-like is a protein that in humans is encoded by the HNRNPLL gene.[5]

HNRNPLL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WEX, 2E5I
Identifiers
Aliases	HNRNPLL, HNRPLL, SRRF, heterogeneous nuclear ribonucleoprotein L like
External IDs	OMIM: 611208 MGI: 1919942 HomoloGene: 26701 GeneCards: HNRNPLL
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p22.1 Start 38,561,969 bp[1] End 38,603,586 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E3 Start 80,029,487 bp[2] End 80,062,334 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • mRNA binding • nucleic acid binding • RNA binding Cellular component • membrane • cell nucleus Biological process • positive regulation of RNA splicing • mRNA processing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	92906	72692
Ensembl	ENSG00000143889	ENSMUSG00000024095
UniProt	Q8WVV9	Q921F4
RefSeq (mRNA)	NM_001142650 NM_138394	NM_144802
RefSeq (protein)	NP_001136122 NP_612403	NP_659051
Location (UCSC)	Chr 2: 38.56 – 38.6 Mb	Chr 17: 80.03 – 80.06 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000143889 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024095 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Heterogeneous nuclear ribonucleoprotein L-like".
6. Oberdoerffer S, Moita LF, Neems D, Freitas RP, Hacohen N, Rao A (August 2008). "Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL". Science. 321 (5889): 686–91. doi:10.1126/science.1157610. PMC 2791692. PMID 18669861.

Further reading

• Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y (November 2011). "Proteomic dissection of the von Hippel-Lindau (VHL) interactome". Journal of Proteome Research. 10 (11): 5175–82. doi:10.1021/pr200642c. PMC 3208728. PMID 21942715.
• Topp JD, Jackson J, Melton AA, Lynch KW (October 2008). "A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4". RNA. 14 (10): 2038–49. doi:10.1261/rna.1212008. PMC 2553740. PMID 18719244.
• Wu Z, Yates AL, Hoyne GF, Goodnow CC (July 2010). "Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation". Journal of Immunology. 185 (1): 231–8. doi:10.4049/jimmunol.0903625. PMID 20505149.
• Fedorova OA, Moiseeva TN, Nikiforov AA, Tsimokha AS, Livinskaya VA, Hodson M, Bottrill A, Evteeva IN, Ermolayeva JB, Kuznetzova IM, Turoverov KK, Eperon I, Barlev NA (December 2011). "Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism". Biochemical and Biophysical Research Communications. 416 (3–4): 258–65. doi:10.1016/j.bbrc.2011.10.126. PMID 22079093.
• Shur I, Ben-Avraham D, Benayahu D (June 2004). "Alternatively spliced isoforms of a novel stromal RNA regulating factor". Gene. 334: 113–21. doi:10.1016/j.gene.2004.03.012. PMID 15256261.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.