HMHA1

Minor histocompatibility protein HA-1 is a protein that in humans is encoded by the HMHA1 gene.[5][6][7]

ARHGAP45
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3D25, 3FT3
Identifiers
Aliases	ARHGAP45, HA-1, HLA-HA1, HMHA1, histocompatibility (minor) HA-1, Rho GTPase activating protein 45
External IDs	OMIM: 601155 MGI: 1917969 HomoloGene: 69120 GeneCards: ARHGAP45
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 1,065,923 bp[1] End 1,086,628 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 80,016,653 bp[2] End 80,031,472 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • metal ion binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity Cellular component • cytosol • extracellular region • secretory granule lumen • azurophil granule lumen • cytoplasm • cell membrane • membrane • ruffle membrane • cell projection Biological process • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • GO:0007243 intracellular signal transduction • regulation of small GTPase mediated signal transduction • signal transduction • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23526	70719
Ensembl	ENSG00000180448	ENSMUSG00000035697
UniProt	Q92619	Q3TBD2
RefSeq (mRNA)	NM_001258328 NM_001282334 NM_001282335 NM_012292 NM_001321232	NM_001142701 NM_027521 NM_001347074
RefSeq (protein)	NP_001245257 NP_001269263 NP_001269264 NP_001308161 NP_036424	NP_001136173 NP_001334003 NP_081797
Location (UCSC)	Chr 19: 1.07 – 1.09 Mb	Chr 10: 80.02 – 80.03 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000180448 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035697 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wilke M, Pool J, den Haan JM, Goulmy E (Jan 1999). "Genomic identification of the minor histocompatibility antigen HA-1 locus by allele-specific PCR". Tissue Antigens. 52 (4): 312–317. doi:10.1111/j.1399-0039.1998.tb03053.x. PMID 9820596.
6. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–329. doi:10.1093/dnares/3.5.321. PMID 9039502.
7. "Entrez Gene: HMHA1 histocompatibility (minor) HA-1".

Further reading

• van Lochem E, van der Keur M, Mommaas AM, et al. (1997). "Functional expression of minor histocompatibility antigens on human peripheral blood dendritic cells and epidermal Langerhans cells". Transpl. Immunol. 4 (2): 151–157. doi:10.1016/S0966-3274(96)80009-8. hdl:1887/2991. PMID 8843592.
• Aróstegui JI, Gallardo D, Rodríguez-Luaces M, et al. (2001). "Genomic typing of minor histocompatibility antigen HA-1 by reference strand mediated conformation analysis (RSCA)". Tissue Antigens. 56 (1): 69–76. doi:10.1034/j.1399-0039.2000.560109.x. PMID 10958358.
• Kaminski WE, Piehler A, Schmitz G (2001). "Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene". Biochem. Biophys. Res. Commun. 278 (3): 782–789. doi:10.1006/bbrc.2000.3880. PMID 11095984.
• Gillespie G, Mutis T, Schrama E, et al. (2002). "HLA class I-minor histocompatibility antigen tetramers select cytotoxic T cells with high avidity to the natural ligand". Hematol. J. 1 (6): 403–10. doi:10.1038/sj/thj/6200065. PMID 11920221.
• Fujii N, Hiraki A, Ikeda K, et al. (2002). "Expression of minor histocompatibility antigen, HA-1, in solid tumor cells". Transplantation. 73 (7): 1137–1141. doi:10.1097/00007890-200204150-00022. PMID 11965046. S2CID 21504762.
• Mutis T, Blokland E, Kester M, et al. (2002). "Generation of minor histocompatibility antigen HA-1-specific cytotoxic T cells restricted by nonself HLA molecules: a potential strategy to treat relapsed leukemia after HLA-mismatched stem cell transplantation". Blood. 100 (2): 547–552. doi:10.1182/blood-2002-01-0024. PMID 12091347.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wilke M, Dolstra H, Maas F, et al. (2004). "Quantification of the HA-1 gene product at the RNA level; relevance for immunotherapy of hematological malignancies". Hematol. J. 4 (5): 315–320. doi:10.1038/sj.thj.6200318. PMID 14502255.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
• Kotzampasaki EM, Spyropoulou-Vlachou MS, Kalofoutis C, et al. (2005). "Minor histocompatibility antigen HA-1 and HPA-5 polymorphisms in HLA-identical related bone marrow transplantation". Transplant. Proc. 36 (6): 1735–1738. doi:10.1016/j.transproceed.2004.06.007. PMID 15350465.
• Mommaas B, Stegehuis-Kamp JA, van Halteren AG, et al. (2005). "Cord blood comprises antigen-experienced T cells specific for maternal minor histocompatibility antigen HA-1". Blood. 105 (4): 1823–1827. doi:10.1182/blood-2004-07-2832. PMID 15498856.
• Harangi M, Kaminski WE, Fleck M, et al. (2005). "Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjögren's syndrome". Eur. J. Immunol. 35 (1): 305–317. doi:10.1002/eji.200425406. PMID 15593299.
• Krishnan NS, Higgins RM, Lam FT, et al. (2007). "HA-1 mismatch has significant effect in chronic allograft nephropathy in clinical renal transplantation". Transplant. Proc. 39 (5): 1439–1445. doi:10.1016/j.transproceed.2007.02.066. PMID 17580157.