HIP1R

Huntingtin-interacting protein 1-related protein is a protein that in humans is encoded by the HIP1R gene.[5][6]

HIP1R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1R0D
Identifiers
Aliases	HIP1R, HIP12, HIP3, ILWEQ, huntingtin interacting protein 1 related
External IDs	OMIM: 605613 MGI: 1352504 HomoloGene: 78348 GeneCards: HIP1R
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 122,834,453 bp[1] End 122,862,961 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 123,973,628 bp[2] End 124,005,558 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • actin binding • GO:0001948 protein binding • phospholipid binding • phosphatidylinositol binding • phosphatidylinositol-4,5-bisphosphate binding • phosphatidylinositol-3,4,5-trisphosphate binding • SH3 domain binding • clathrin binding • clathrin light chain binding • clathrin adaptor activity • protein homodimerization activity • phosphatidylinositol-3,4-bisphosphate binding • protein heterodimerization activity • actin filament binding • phosphatidylinositol-3,5-bisphosphate binding • identical protein binding Cellular component • perinuclear region of cytoplasm • clathrin-coated pit • cytoskeleton • clathrin-coated vesicle membrane • intracellular membrane-bounded organelle • endomembrane system • membrane • cytoplasmic vesicle • clathrin-coated vesicle • cytoplasm • mitochondrion • cytosol • cell cortex • GO:0097483, GO:0097481 postsynaptic density • apical plasma membrane • ruffle membrane • dendrite cytoplasm • neuronal cell body • dendritic spine • synaptic membrane • AP-2 adaptor complex • actin cortical patch Biological process • endocytosis • receptor-mediated endocytosis • apoptotic process • activation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of endocytosis • negative regulation of actin filament polymerization • positive regulation of protein binding • regulation of actin cytoskeleton organization • negative regulation of Arp2/3 complex-mediated actin nucleation • positive regulation of apoptotic process • negative regulation of apoptotic process • positive regulation of epidermal growth factor receptor signaling pathway • clathrin coat assembly • protein stabilization • digestive system development • regulation of gastric acid secretion • membrane organization • positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway • positive regulation of clathrin coat assembly • positive regulation of platelet-derived growth factor receptor-beta signaling pathway • regulation of clathrin-dependent endocytosis • actin filament organization • positive regulation of receptor-mediated endocytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9026	29816
Ensembl	ENSG00000130787	ENSMUSG00000000915
UniProt	O75146	Q9JKY5
RefSeq (mRNA)	NM_001303097 NM_001303099 NM_003959	NM_145070
RefSeq (protein)	NP_001290026 NP_001290028 NP_003950	NP_659507
Location (UCSC)	Chr 12: 122.83 – 122.86 Mb	Chr 5: 123.97 – 124.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000130787 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000915 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Brett TJ, Legendre-Guillemin V, McPherson PS, Fremont DH (Feb 2006). "Structural definition of the F-actin-binding THATCH domain from HIP1R". Nat Struct Mol Biol. 13 (2): 121–30. doi:10.1038/nsmb1043. PMID 16415883. S2CID 1456946.
6. "Entrez Gene: HIP1R huntingtin interacting protein 1 related".

Further reading

• Parker JA, Metzler M, Georgiou J, et al. (2007). "Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity". J. Neurosci. 27 (41): 11056–64. doi:10.1523/JNEUROSCI.1941-07.2007. PMC 6672856. PMID 17928447.
• Bradley SV, Hyun TS, Oravecz-Wilson KI, et al. (2007). "Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1". Hum. Mol. Genet. 16 (11): 1279–92. doi:10.1093/hmg/ddm076. PMID 17452370.
• Provençal N, Shink E, Harvey M, et al. (2005). "Analysis of a variable number tandem repeat polymorphism in the huntingtin interacting protein-1 related gene for anticipation in bipolar affective disorder". Prog. Neuropsychopharmacol. Biol. Psychiatry. 28 (8): 1299–303. doi:10.1016/j.pnpbp.2004.07.001. PMID 15588756. S2CID 23161289.
• Senetar MA, Foster SJ, McCann RO (2005). "Intrasteric inhibition mediates the interaction of the I/LWEQ module proteins Talin1, Talin2, Hip1, and Hip12 with actin". Biochemistry. 43 (49): 15418–28. doi:10.1021/bi0487239. PMID 15581353.
• Navarro-Lérida I, Martínez Moreno M, Roncal F, et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics. 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703. S2CID 8868600.
• Engqvist-Goldstein AE, Zhang CX, Carreno S, et al. (2004). "RNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery". Mol. Biol. Cell. 15 (4): 1666–79. doi:10.1091/mbc.E03-09-0639. PMC 379265. PMID 14742709.
• Hyun TS, Rao DS, Saint-Dic D, et al. (2004). "HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains". J. Biol. Chem. 279 (14): 14294–306. doi:10.1074/jbc.M312645200. PMID 14732715.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Legendre-Guillemin V, Metzler M, Charbonneau M, et al. (2002). "HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain". J. Biol. Chem. 277 (22): 19897–904. doi:10.1074/jbc.M112310200. PMID 11889126.
• Chopra VS, Metzler M, Rasper DM, et al. (2001). "HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin". Mamm. Genome. 11 (11): 1006–15. doi:10.1007/s003350010195. PMID 11063258. S2CID 19956774.
• Seki N, Muramatsu M, Sugano S, et al. (1999). "Cloning, expression analysis, and chromosomal localization of HIP1R, an isolog of huntingtin interacting protein (HIP1)". J. Hum. Genet. 43 (4): 268–71. doi:10.1007/s100380050087. PMID 9852681.
• Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
• Puigvert A (1976). "Caliceal urodynamics". Urol. Int. 30 (4): 282–96. doi:10.1159/000279990. PMID 1189126.