HEXIM2

Protein HEXIM2 is a protein that in humans is encoded by the HEXIM2 gene.[5][6]

HEXIM2
Identifiers
Aliases	HEXIM2, L3, hexamethylene bisacetamide inducible 2, HEXIM P-TEFb complex subunit 2
External IDs	OMIM: 615695 MGI: 1918309 HomoloGene: 16946 GeneCards: HEXIM2
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 45,160,700 bp[1] End 45,170,040 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1 Start 103,132,429 bp[2] End 103,139,876 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • cyclin-dependent protein serine/threonine kinase inhibitor activity • snRNA binding • GO:0001948 protein binding • 7SK snRNA binding • identical protein binding Cellular component • nucleoplasm • cytoplasm • cytosol • nuclear speck • cell nucleus Biological process • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • negative regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of protein serine/threonine kinase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	124790	71059
Ensembl	ENSG00000168517	ENSMUSG00000043372
UniProt	Q96MH2	Q3TVI4
RefSeq (mRNA)	NM_001303436 NM_001303437 NM_001303438 NM_001303439 NM_001303440 NM_001303441 NM_001303442 NM_001303443 NM_001303444 NM_144608	NM_001130515 NM_001130516 NM_027658
RefSeq (protein)	NP_001290365 NP_001290366 NP_001290367 NP_001290368 NP_001290369 NP_001290370 NP_001290371 NP_001290372 NP_001290373 NP_653209	NP_001123987 NP_001123988 NP_081934
Location (UCSC)	Chr 17: 45.16 – 45.17 Mb	Chr 11: 103.13 – 103.14 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000168517 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043372 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Michels AA, Nguyen VT, Fraldi A, Labas V, Edwards M, Bonnet F, Lania L, Bensaude O (Jun 2003). "MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner". Mol Cell Biol. 23 (14): 4859–69. doi:10.1128/MCB.23.14.4859-4869.2003. PMC 162212. PMID 12832472.
6. "Entrez Gene: HEXIM2 hexamthylene bis-acetamide inducible 2".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Petroziello J, Yamane A, Westendorf L, et al. (2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene. 23 (46): 7734–45. doi:10.1038/sj.onc.1207921. PMID 15334068.
• Yik JH, Chen R, Pezda AC, Zhou Q (2005). "Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription". J. Biol. Chem. 280 (16): 16368–76. doi:10.1074/jbc.M500912200. PMID 15713661.
• Byers SA, Price JP, Cooper JJ, et al. (2005). "HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK". J. Biol. Chem. 280 (16): 16360–7. doi:10.1074/jbc.M500424200. PMID 15713662.
• Li Q, Price JP, Byers SA, et al. (2005). "Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186". J. Biol. Chem. 280 (31): 28819–26. doi:10.1074/jbc.M502712200. PMID 15965233.
• Fraldi A, Varrone F, Napolitano G, et al. (2006). "Inhibition of Tat activity by the HEXIM1 protein". Retrovirology. 2 (1): 42. doi:10.1186/1742-4690-2-42. PMC 1183248. PMID 15992410.