HECW1

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 is a protein that in humans is encoded by the HECW1 gene.[5] In human it has 1606 amino acids (179.5 kDa) and isoelectric point of 5.18.[6]

HECW1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3L4H
Identifiers
Aliases	HECW1, NEDL1, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
External IDs	OMIM: 610384 MGI: 2444115 HomoloGene: 9004 GeneCards: HECW1
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p14.1-p13 Start 43,112,629 bp[1] End 43,566,001 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A1|13 5.29 cM Start 14,226,438 bp[2] End 14,523,228 bp[2]
Gene ontology Molecular function • transferase activity • ubiquitin-protein transferase activity • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity Cellular component • cytosol • cytoplasm Biological process • negative regulation of canonical Wnt signaling pathway • protein ubiquitination • proteasome-mediated ubiquitin-dependent protein catabolic process • protein polyubiquitination • ubiquitin-dependent protein catabolic process • positive regulation of protein catabolic process • regulation of dendrite morphogenesis • negative regulation of sodium ion transmembrane transporter activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23072	94253
Ensembl	ENSG00000002746	ENSMUSG00000021301
UniProt	Q76N89	Q8K4P8
RefSeq (mRNA)	NM_001287059 NM_015052	NM_001081348 NM_153130 NM_178809
RefSeq (protein)	NP_001273988 NP_055867	NP_001074817
Location (UCSC)	Chr 7: 43.11 – 43.57 Mb	Chr 13: 14.23 – 14.52 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000002746 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021301 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1".
6. Kozlowski LP (October 2016). "IPC - Isoelectric Point Calculator". Biology Direct. 11 (1): 55. doi:10.1186/s13062-016-0159-9. PMC 5075173. PMID 27769290. Archived from the original on 2013-04-29. Retrieved 2020-01-06.

Further reading

• Miyazaki K, Fujita T, Ozaki T, Kato C, Kurose Y, Sakamoto M, Kato S, Goto T, Itoyama Y, Aoki M, Nakagawara A (March 2004). "NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1". The Journal of Biological Chemistry. 279 (12): 11327–35. doi:10.1074/jbc.M312389200. PMID 14684739.
• Chansard M, Wang J, Tran HC, Neumayer G, Shim SY, Park YU, Belzil C, Le HT, Park SK, Nguyen MD (January 2011). "The cytoskeletal protein Ndel1 regulates dynamin 2 GTPase activity". PLOS ONE. 6 (1): e14583. doi:10.1371/journal.pone.0014583. PMC 3026782. PMID 21283621.
• Sherva R, Tripodis Y, Bennett DA, Chibnik LB, Crane PK, de Jager PL, Farrer LA, Saykin AJ, Shulman JM, Naj A, Green RC (January 2014). "Genome-wide association study of the rate of cognitive decline in Alzheimer's disease". Alzheimer's & Dementia. 10 (1): 45–52. doi:10.1016/j.jalz.2013.01.008. PMC 3760995. PMID 23535033.
• Li Y, Ozaki T, Kikuchi H, Yamamoto H, Ohira M, Nakagawara A (June 2008). "A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent manner". Oncogene. 27 (26): 3700–9. doi:10.1038/sj.onc.1211032. PMID 18223681.
• Harvey KF, Dinudom A, Cook DI, Kumar S (March 2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". The Journal of Biological Chemistry. 276 (11): 8597–601. doi:10.1074/jbc.C000906200. PMID 11244092.
• Zhang L, Haraguchi S, Koda T, Hashimoto K, Nakagawara A (2011). "Muscle atrophy and motor neuron degeneration in human NEDL1 transgenic mice". Journal of Biomedicine & Biotechnology. 2011: 1–7. doi:10.1155/2011/831092. PMC 2952905. PMID 20976258.
• Cui Y, He S, Xing C, Lu K, Wang J, Xing G, Meng A, Jia S, He F, Zhang L (May 2011). "SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1". The EMBO Journal. 30 (13): 2675–89. doi:10.1038/emboj.2011.155. PMC 3155294. PMID 21572392.
• Shinada K, Tsukiyama T, Sho T, Okumura F, Asaka M, Hatakeyama S (January 2011). "RNF43 interacts with NEDL1 and regulates p53-mediated transcription". Biochemical and Biophysical Research Communications. 404 (1): 143–7. doi:10.1016/j.bbrc.2010.11.082. hdl:2115/44929. PMID 21108931.
• Levine DM, Ek WE, Zhang R, Liu X, Onstad L, Sather C, Lao-Sirieix P, Gammon MD, Corley DA, Shaheen NJ, Bird NC, Hardie LJ, Murray LJ, Reid BJ, Chow WH, Risch HA, Nyrén O, Ye W, Liu G, Romero Y, Bernstein L, Wu AH, Casson AG, Chanock SJ, Harrington P, Caldas I, Debiram-Beecham I, Caldas C, Hayward NK, Pharoah PD, Fitzgerald RC, Macgregor S, Whiteman DC, Vaughan TL (December 2013). "A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus". Nature Genetics. 45 (12): 1487–93. doi:10.1038/ng.2796. PMC 3840115. PMID 24121790.