Glycerol dehydratase
In enzymology, a glycerol dehydratase (EC 4.2.1.30) is an enzyme that catalyzes the chemical reaction
- glycerol 3-hydroxypropanal + H2O
| glycerol dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.1.30 | ||||||||
| CAS number | 9077-68-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Hence, this enzyme has one substrate, glycerol, and two products, 3-hydroxypropanal and H2O.
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is glycerol hydro-lyase (3-hydroxypropanol-forming). Other names in common use include glycerol dehydrase, and glycerol hydro-lyase. This enzyme participates in glycerolipid metabolism. It employs one cofactor, cobalamin.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1IWP and 1MMF.
References
- Forage RG, Foster MA (1982). "Glycerol fermentation in Klebsiella pneumoniae: functions of the coenzyme B12-dependent glycerol and diol dehydratases". J. Bacteriol. 149 (2): 413–9. doi:10.1128/JB.149.2.413-419.1982. PMC 216523. PMID 7035429.
- Schneider Z, Larsen EG, Jacobson G, Johnson BC, Pawelkiewicz J (1970). "Purification and properties of glycerol dehydrase". J. Biol. Chem. 245 (13): 3388–96. PMID 4989992.
- Schneider Z, Pawelkiewicz J (1966). "The properties of glycerol dehydratase isolated from Aerobacter aerogenes, and the properties of the apoenzyme subunits". Acta Biochim. Pol. 13 (4): 311–28. PMID 5962440.
- SMILEY KL, SOBOLOV M (1962). "A cobamide-requiring glycerol dehydrase from an acrolein-forming Lactobacillus". Arch. Biochem. Biophys. 97 (3): 538–43. doi:10.1016/0003-9861(62)90118-2. PMID 14039344.
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