Gingipain

Gingipains are a family of proteases secreted by Porphyromonas gingivalis. Among other functions, it works to degrade cytokines, thereby downregulating the host response in the form of reduced inflammation.[1] Gingipain has been studied for its potential role in the development of Alzheimer's Disease.[2][3]

References
  1. Stathopoulou, PG. Epithelial cell pro-inflammatory cytokine response differs across dental plaque bacterial species. J Clin Perio 2010;37:24–29
  2. Dominy, S.S., Lynch, C., Ermini, F., Benedyk, M., Marczyk, A., Konradi, A., Nguyen, M., Haditsch, U., Raha, D., Griffin, C. and Holsinger, L.J., 2019. Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Science Advances, 5(1), p.eaau3333.
  3. New Scientist 29 January 2019
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