Furethidine
Furethidine[1] is a 4-phenylpiperidine derivative that is related to the clinically used opioid analgesic drug pethidine (meperidine),[2] but with around 25x higher potency.[3]
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| Other names | ethyl 4-phenyl-1-(2-tetrahydrofurfuryloxyethyl)piperidine-4-carboxylate |
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| ECHA InfoCard | 100.017.451  |
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| Formula | C21H31NO4 |
| Molar mass | 361.482 g·mol−1 |
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Furethidine is not currently used in medicine and is a Class A/Schedule I drug which is controlled under UN drug conventions. It has similar effects to other opioid derivatives, such as analgesia, sedation, nausea and respiratory depression.[4] In the United States it is a Schedule I Narcotic controlled substance with the ACSCN of 9626.[5]
References
- GB 797448, Frearson PM, Stern ES, "Novel piperidine compounds and their production", published 2 July 1958, assigned to J F Macfarlan & Co Ltd
- Maul C, Buschmann H, Sundermann B (2005). "Opioids: 3.3 Synthetic Opioids.". Analgesics. pp. 159–169. ISBN 978-3-527-30403-5.
- Casy AF, Parfitt RY. Opioid analgesics, chemistry and receptors. 1986, Plenum Press, New York. pp 234-235. ISBN 0-306-42130-5
- Cahal DA, Dare JG, Keith D (February 1961). "A sequential trial of analgesics in labour". The Journal of Obstetrics and Gynaecology of the British Commonwealth. 68: 88–93. doi:10.1111/j.1471-0528.1961.tb02689.x. PMID 13689779. S2CID 27397119.
- "Controlled Substances - Alphabetical Order" (PDF). Diversion Control Division. Drug Enforcement Agency, U.S. Department of Justice. 2020. p. 9.
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