Frank Gannon (molecular biologist)

Frank (Bernard Francis Xavier) Gannon (born 1947, Ireland) is the seventh Director of QIMR Berghofer Medical Research Institute in Brisbane, Australia (2011 – present).[1] He is a molecular biologist and has held high-profile appointments in scientific management and research in Ireland, England, the United States, France, Germany and Australia.[2]

Frank Gannon, director, QIMR Berghofer

Career

Education

In 1970, Gannon completed a Bachelor of Science with Honours at the National University of Ireland Galway (then known as University College Galway).[1] He then moved to the University of Leicester, where he obtained his PhD in 1973.[3]

Early career

In 1973, Gannon joined the laboratory of Jack Gorski at the University of Wisconsin-Madison as a post-doctoral researcher.[4] There, he worked on the oestrogen receptor and investigated the mechanisms that resulted in the receptor being localised in the nucleus. This work led to a significant paper being published in the Annual Review of Physiology.[5]

In 1975, Gannon moved to the University of Strasbourg, France to take up a post-doctoral fellowship in the laboratory of Professor Pierre Chambon.[3] In 1977, while still in this role, Gannon was appointed Chargé de Recherche of the French National Institute of Health and Medical Research (INSERM).[4] During this time he was involved in a number of DNA cloning experiments which culminated in the isolation of the chicken ovalbumin gene.[6]

In 1981 Gannon returned to University College Galway (UCG) in Ireland and took up a position in the Department of Microbiology.[3]

EMBO and EMBL

From 1994 to 2007, Gannon was the Executive Director (Secretary at the time) of the European Molecular Biology Organisation (EMBO) and Senior Scientist at the European Molecular Biology Laboratory (EMBL), based in Germany.[7]

During this time, Gannon became the founding editor of the journal EMBO Reports and contributed a monthly editorial on a range of topics, including the impact of research on society.[1] During his time at EMBO, Gannon also showed a commitment to female researchers by analysing fellowship application data to conduct an objective assessment of the potential causes for the lower success rate of female applicants for postdoctoral fellowships.[8]

During this period, Gannon also maintained an active research group that focussed on the manner in which the oestrogen receptor (ER) controlled gene expression. Outstanding from a series of high-impact studies was the demonstration of the cyclical nature of the binding of the ER to its DNA response element that resulted in the sequential recruitment of chromatin-modifying enzymes and ultimately the RNA polymerase, prior to that sequence of events being reversed.[9] Pursuing this research approach, Gannon's team subsequently showed that DNA methylation (previously thought to be an indelible mark) was also subject to dynamic and cyclical change.[10]

Scientific Foundation Ireland

In 2007, after 13 years at the helm of EMBO, Gannon accepted the position of Director General of Science Foundation Ireland (SFI).[7] SFI had been established by the Irish government 10 years earlier to recruit and retain high-quality researchers based on their excellence, with the expectation that this would provide an extra offering and possibilities for multi-national and local companies that had activities particularly in the areas of pharmaceuticals, information technology and energy.[11]

QIMR Berghofer Medical Research Institute

Soon after Gannon moved to Dublin for the SFI position, Ireland faced a major economic setback that ultimately required a bailout from the EU and the International Monetary Fund.[12] Faced with the uncertainty of future funding for SFI, Gannon decided to move again, and in 2010, he accepted the position of Director and CEO of the Queensland Institute of Medical Research (QIMR) in Brisbane, Australia.[2] Gannon started at QIMR in January 2011. The name of the Institute was changed to QIMR Berghofer Medical Research Institute (QIMR Berghofer), following Gannon's successful attraction of a major donation from Clive Berghofer – a philanthropist and property developer from Toowoomba.[13]

At QIMR Berghofer, Gannon has restructured the Institute so that it now has four programs (Cancer, Infectious Diseases, Mental Health, and Chronic Disorders) and four departments (Genetics and Computational Biology, Immunology, Cell and Molecular Biology, and Population Health.[14] Gannon has made a specific effort to extend translation of the Institute's research, through industry, to the clinic.[15] He has also placed emphasis on developing better contacts with Asia, which has resulted in increased research and commercial collaborations, particularly with China and India.[16] He also reactivated his research group focusing on enzymes involved in epigenetic modifications.[17]

Other appointments
  • Vice-President of the European Heads of Research Council
  • Advisor to the EU Commissioner for Research and Innovation
  • Co-founded of the European Life Sciences Forum and the Initiative for Science in Europe, which played significant roles in the establishment of the European Research Council
  • Scientific advisory board member, International Institute for Molecular and Cell Biology (Warsaw, Poland)
  • Elected member of the Royal Irish Academy
  • Elected member of Academia Europae
  • Elected member of the European Academy of Cancer Sciences
  • Elected member of the Queensland Arts and Sciences Academy
  • Elected member of the Mexican National Academy of Medicine
  • Elected board member of the Australian Academy of Health and Medical Research
  • Founder of Bimini Ltd
  • Founder of Elara Pharmaceuticals[7][3][1]
  • Elected Fellow of the Australian Academy of Health and Medical Sciences[18]

Awards and honours
  • 1999: Honorary doctorate from the Josef Attila University, Szeged, Hungary
  • 2008: Honorary doctorate from Queens University, Belfast, Northern Ireland
  • 2008: Honorary doctorate from The University of Queensland, Australia[3]

References
  1. "Our Director: Professor Frank Gannon". QIMR Berghofer Medical Research Institute. Retrieved 8 February 2017.
  2. "QIMR appoints new director and CEO" (media release)". QIMR Berghofer Medical Research Institute. January 2010. Retrieved 8 February 2017.
  3. "Staff@QIMR Berghofer: Professor Frank Gannon". QIMR Berghofer Medical Research Institute. Retrieved 8 February 2017.
  4. "Professor Frank Gannon". UQ Centre for Clinical Research. Missing or empty |url= (help)
  5. Gorski, J.; Gannon, F. (1976). "Current models of steroid hormone action: A critique". Annual Review of Physiology. 38: 425–450. doi:10.1146/annurev.ph.38.030176.002233. PMID 176920.
  6. Gannon, F; O'Hare, K; Perrin, F; Lepennec, J.P.; Benoist, C; Cochet, M; Breathnach, R; Royal, A; Garapin, A; Cami, B; Chambon, P (1979). "Organization and sequences at the 5' end of a cloned complete ovalbumin gene". Nature. 278 (5703): 428–434. Bibcode:1979Natur.278..428G. doi:10.1038/278428a0. PMID 450048. S2CID 4347021.
  7. "Professor Frank Gannon". Association of Australian Medical Research Institutes. Retrieved 8 February 2017.
  8. Ledin, A; Bornmann, L; Gannon, F; Wallon, G (2007). "A persistent problem. Traditional gender roles hold back female scientists". EMBO Reports. 8 (11): 982–987. doi:10.1038/sj.embor.7401109. PMC 2247380. PMID 17972895.
  9. Metivier, R; Penot, G; Hubner, M.R.; Reid, G; Brand, H; Kos, M; Gannon, F (2003). "Estrogen Receptor-α directs ordered, cyclical and combinatorial recruitment of cofactors on a natural target promoter". Cell. 115 (6): 751–763. doi:10.1016/S0092-8674(03)00934-6. PMID 14675539. S2CID 145525.
  10. Kangaspeska, S; Stride, B; Metivier, R; Polycarpou-Schwarz, M; Ibberson, D; Carmouche, RP; Benes, V; Gannon, F; Reid, G (2008). "Transient cyclical methylation of promoter DNA". Nature. 452 (7183): 112–115. Bibcode:2008Natur.452..112K. doi:10.1038/nature06640. PMID 18322535. S2CID 4422829.
  11. "History". Science Foundation Ireland. Retrieved 8 February 2017.
  12. "Irish Republic 85bn euro bail-out agreed". BBC News. 28 November 2010.
  13. "Clive Berghofer gives record $50.1 million to QIMR" (media release)". QIMR Berghofer Medical Research Institute. January 2013. Retrieved 8 February 2017.
  14. "Our research". QIMR Berghofer Medical Research Institute. Retrieved 8 February 2017.
  15. "CSL to support QIMR Berghofer translational research". QIMR Berghofer Medical Research Institute. 5 June 2016. Retrieved 8 February 2017.
  16. "QIMR Berghofer signs MOU with global genomics giant (media release)". QIMR Berghofer Medical Research Institute. 21 October 2016. Retrieved 8 February 2017.
  17. Casciello, F; Windloch, K; Gannon, F; Lee, JS (2015). "Functional Role of G9a Histone Methyltransferase in Cancer". Front Immunol. 6: 487. doi:10.3389/fimmu.2015.00487. PMC 4585248. PMID 26441991.
  18. "Fellowship | AAHMS – Australian Academy of Health and Medical Sciences". www.aahms.org. Retrieved 26 June 2018.
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