FGFBP1

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.[5][6][7]

FGFBP1
Identifiers
AliasesFGFBP1, FGF-BP, FGF-BP1, FGFBP, FGFBP-1, HBP17, fibroblast growth factor binding protein 1
External IDsOMIM: 607737 MGI: 1096350 HomoloGene: 3766 GeneCards: FGFBP1
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4p15.32Start15,935,577 bp[1]
End15,938,740 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9982

14181

Ensembl

ENSG00000137440

ENSMUSG00000048373

UniProt

Q14512

O70514

RefSeq (mRNA)

NM_005130

NM_001271616
NM_008009

RefSeq (protein)

NP_005121

NP_001258545
NP_032035

Location (UCSC)Chr 4: 15.94 – 15.94 MbChr 5: 43.98 – 43.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FGFBP1, or HBP17, binds to both acidic (FGF1; MIM 131220) and basic (FGF2; MIM 134920) fibroblast growth factors in a reversible manner. It also binds to perlecan (HSPG2; MIM 142461).[supplied by OMIM][7]

Interactions

FGFBP1 has been shown to interaction with Perlecan.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000137440 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000048373 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mongiat M, Otto J, Oldershaw R, Ferrer F, Sato JD, Iozzo RV (Mar 2001). "Fibroblast growth factor-binding protein is a novel partner for perlecan protein core". J Biol Chem. 276 (13): 10263–71. doi:10.1074/jbc.M011493200. PMID 11148217.
  6. Wu DQ, Kan MK, Sato GH, Okamoto T, Sato JD (Oct 1991). "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors". J Biol Chem. 266 (25): 16778–85. PMID 1885605.
  7. "Entrez Gene: FGFBP1 fibroblast growth factor binding protein 1".

Further reading


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