FAM132A

Family with sequence similarity 132, member A also known as adipolin is a protein that in humans is encoded by the FAM132A gene.[5] Adipolin is an adipokine.

C1QTNF12
Identifiers
Aliases	C1QTNF12, C1QDC2, CTRP12, FAM132A, family with sequence similarity 132 member A, C1q and TNF related 12
External IDs	OMIM: 616593 MGI: 1914639 HomoloGene: 12123 GeneCards: C1QTNF12
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.33 Start 1,242,446 bp[1] End 1,246,722 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E2|4 87.66 cM Start 155,962,318 bp[2] End 155,966,629 bp[2]
Gene ontology Molecular function • hormone activity Cellular component • extracellular region • extracellular Biological process • positive regulation of glucose import • negative regulation of gluconeogenesis • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin receptor signaling pathway • positive regulation of protein kinase B signaling • regulation of glucose metabolic process • negative regulation of inflammatory response • regulation of glucose import • regulation of receptor activity • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	388581	67389
Ensembl	ENSG00000184163	ENSMUSG00000023571
UniProt	Q5T7M4	Q8R2Z0
RefSeq (mRNA)	NM_001014980	NM_026125
RefSeq (protein)	NP_001014980	NP_080401
Location (UCSC)	Chr 1: 1.24 – 1.25 Mb	Chr 4: 155.96 – 155.97 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000184163 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023571 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Family with sequence similarity 132, member A".

Further reading

• Wei Z, Lei X, Seldin MM, Wong GW (October 2012). "Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity". J. Biol. Chem. 287 (43): 35804–14. doi:10.1074/jbc.M112.365965. PMC 3476250. PMID 22942287.
• Enomoto T, Ohashi K, Shibata R, Higuchi A, Maruyama S, Izumiya Y, Walsh K, Murohara T, Ouchi N (October 2011). "Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism". J. Biol. Chem. 286 (40): 34552–8. doi:10.1074/jbc.M111.277319. PMC 3186379. PMID 21849507.
• Conde J, Scotece M, López V, Gómez R, Lago F, Pino J, Gómez-Reino JJ, Gualillo O (January 2013). "Expression and modulation of adipolin/C1qdc2: a novel adipokine in human and murine ATDC-5 chondrocyte cell line". Ann. Rheum. Dis. 72 (1): 140–2. doi:10.1136/annrheumdis-2012-201693. PMID 22736092. S2CID 20772682.