FAAH2

Fatty acid amide hydrolase 2 or FAAH2 (EC 3.5.1.99, oleamide hydrolase 2, anandamide amidohydrolase 2) is a member of the serine hydrolase family of enzymes.[3]

FAAH2
Identifiers
Aliases	FAAH2, AMDD, fatty acid amide hydrolase 2
External IDs	OMIM: 300654 HomoloGene: 45263 GeneCards: FAAH2
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.21 Start 57,286,706 bp[1] End 57,489,196 bp[1]
Gene ontology Molecular function • hydrolase activity • anandamide amidohydrolase activity • fatty acid amide hydrolase activity • oleamide hydrolase activity Cellular component • integral component of membrane • lipid droplet • membrane Biological process • arachidonic acid metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	158584	n/a
Ensembl	ENSG00000165591	n/a
UniProt	Q6GMR7	n/a
RefSeq (mRNA)	NM_174912 NM_001353840 NM_001353841	n/a
RefSeq (protein)	NP_777572 NP_001340769 NP_001340770	n/a
Location (UCSC)	Chr X: 57.29 – 57.49 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Fatty acid amide hydrolase 2 degrades endocannabinoids and defects in this enzyme have been associated with neurologic and psychiatric disorders.[4]

See also

• Fatty acid amide hydrolase

References

1. GRCh38: Ensembl release 89: ENSG00000165591 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Wei BQ, Mikkelsen TS, McKinney MK, Lander ES, Cravatt BF (December 2006). "A second fatty acid amide hydrolase with variable distribution among placental mammals". The Journal of Biological Chemistry. 281 (48): 36569–78. doi:10.1074/jbc.M606646200. PMID 17015445.
4. Sirrs S, van Karnebeek CD, Peng X, Shyr C, Tarailo-Graovac M, Mandal R, et al. (March 2015). "Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms". Orphanet Journal of Rare Diseases. 10: 38. doi:10.1186/s13023-015-0248-3. PMC 4423390. PMID 25885783.