Examples of in vitro transdifferentiation by initial epigenetic activation phase approach

List:[1]

• Human dermal fibroblasts → multilineage blood progenitors (Oct4 and cytokine treatment)[2]
• Mouse dermal fibroblasts → polygonal hyaline chondrogenic cells (Klf4, c-Myc, Sox9)[3]
• Mouse dermal fibroblasts → cardiomyocytes (Oct4, Sox2, Klf4, JI1 and Bmp4)[4]
• Fibroblasts → neural stem/progenitor cells (Oct4, Sox2, c-Myc, Klf4)[5]

See also

• Transdifferentiation
• Induced stem cells

References

1. Pournasr, B.; Khaloughi, K.; Salekdeh, G. H.; Totonchi, M.; Shahbazi, E.; Baharvand, H. (2011). "Concise Review: Alchemy of Biology: Generating Desired Cell Types from Abundant and Accessible Cells". Stem Cells. 29 (12): 1933–1941. doi:10.1002/stem.760. PMID 21997905.
2. Szabo, E.; Rampalli, S.; Risueño, R. M.; Schnerch, A.; Mitchell, R.; Fiebig-Comyn, A.; Levadoux-Martin, M.; Bhatia, M. (2010). "Direct conversion of human fibroblasts to multilineage blood progenitors". Nature. 468 (7323): 521–526. doi:10.1038/nature09591. PMID 21057492.
3. Hiramatsu, K.; Sasagawa, S.; Outani, H.; Nakagawa, K.; Yoshikawa, H.; Tsumaki, N. (2011). "Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors". Journal of Clinical Investigation. 121 (2): 640–657. doi:10.1172/JCI44605. PMC 3026734. PMID 21293062.
4. Efe, J. A.; Hilcove, S.; Kim, J.; Zhou, H.; Ouyang, K.; Wang, G.; Chen, J.; Ding, S. (2011). "Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy". Nature Cell Biology. 13 (3): 215–222. doi:10.1038/ncb2164. PMID 21278734.
5. Kim, J.; Efe, J. A.; Zhu, S.; Talantova, M.; Yuan, X.; Wang, S.; Lipton, S. A.; Zhang, K.; Ding, S. (2011). "Direct reprogramming of mouse fibroblasts to neural progenitors". Proceedings of the National Academy of Sciences. 108 (19): 7838–7843. doi:10.1073/pnas.1103113108. PMC 3093517. PMID 21521790.