Estradiol undecylate/norethisterone enanthate

Estradiol undecylate/norethisterone enanthate (EU/NETE) is a combination medication of estradiol undecylate (EU), an estrogen, and norethisterone enanthate (NETE), a progestin, which was developed by Schering for potential use as a combined injectable contraceptive in women but was ultimately never marketed.[1][2][3][4][5][6] It contained 5 to 10 mg EU and 50 to 70 mg NETE in oil solution and was intended for use by intramuscular injection at regular intervals.[1][2][3][4][5][6] Although never commercialized, EU/NETE was found to be effective and well tolerated.[1][2][3][4][5][6]

Estradiol undecylate /
norethisterone enanthate

Estradiol undecylate (top) and norethisterone enanthate (bottom)
Combination of
Estradiol undecylate	Estrogen
Norethisterone enanthate	Progestogen
Clinical data
Other names	EU/NETE
Routes of administration	Intramuscular injection

See also

• Polyestradiol phosphate/medroxyprogesterone acetate
• List of combined sex-hormonal preparations § Estrogens and progestogens

References

1. Karim M, el-Mahgoub S (July 1971). "Conception control by cyclic injections of norethisterone enanthate and estradiol unducelate". Am. J. Obstet. Gynecol. 110 (5): 740–2. doi:10.1016/0002-9378(71)90268-7. PMID 5563241.
2. Toppozada MK (1994). "Existing once-a-month combined injectable contraceptives". Contraception. 49 (4): 293–301. doi:10.1016/0010-7824(94)90029-9. PMID 8013216.
3. Mokhtar K. Toppozada (1983). "Monthly Injectable Contraceptives". In Alfredo Goldsmith; Mokhtar Toppozada (eds.). Long-Acting Contraception. pp. 93–103. OCLC 35018604.
4. Toppozada M (June 1977). "The clinical use of monthly injectable contraceptive preparations". Obstet Gynecol Surv. 32 (6): 335–47. doi:10.1097/00006254-197706000-00001. PMID 865726.
5. Dr. S. S. Kadam (July 2007). Principles of Medicinal Chemistry Volume 2. Pragati Books Pvt. Ltd. pp. 381–. ISBN 978-81-85790-03-9.
6. Newton JR, D'arcangues C, Hall PE (1994). "A review of "once-a-month" combined injectable contraceptives". J Obstet Gynaecol (Lahore). 4 Suppl 1: S1–34. doi:10.3109/01443619409027641. PMID 12290848.