Estradiol cypionate/testosterone enanthate

Estradiol cypionate/testosterone enanthate (EC/TE), sold under the brand name Supligol, is an injectable combination medication of estradiol cypionate (EC), an estrogen, and testosterone enanthate (TE), an androgen/anabolic steroid, which is used in menopausal hormone therapy for women, to treat prostatic hypertrophy in men, to treat osteoporosis, and to suppress lactation in women, among other uses.[1][2] It contains 4 mg EC and 80 mg TE (57.5 mg free testosterone) in oil solution in each ampoule and is administered by intramuscular injection once every 3 to 6 weeks for hormone therapy in women.[1] The medication was marketed by 1976[1] and remains available today in Paraguay.[2]

Androgen replacement therapy formulations and dosages used in women

Route	Medication	Major brand names	Form	Dosage
Oral	Testosterone undecanoate	Andriol, Jatenzo	Capsule	40–80 mg 1x/1–2 days
	Methyltestosterone	Metandren, Estratest	Tablet	0.5–10 mg/day
	Fluoxymesterone	Halotestin	Tablet	1–2.5 mg 1x/1–2 days
	Normethandrone^a	Ginecoside	Tablet	5 mg/day
	Tibolone	Livial	Tablet	1.25–2.5 mg/day
	Prasterone (DHEA)^b	–	Tablet	10–100 mg/day
Sublingual	Methyltestosterone	Metandren	Tablet	0.25 mg/day
Transdermal	Testosterone	Intrinsa	Patch	150–300 μg/day
		AndroGel	Gel, cream	1–10 mg/day
Vaginal	Prasterone (DHEA)	Intrarosa	Insert	6.5 mg/day
Injection	Testosterone propionate^a	Testoviron	Oil solution	25 mg 1x/1–2 weeks
	Testosterone enanthate	Delatestryl, Primodian Depot	Oil solution	25–100 mg 1x/4–6 weeks
	Testosterone cypionate	Depo-Testosterone, Depo-Testadiol	Oil solution	25–100 mg 1x/4–6 weeks
	Testosterone isobutyrate^a	Femandren M, Folivirin	Aqueous suspension	25–50 mg 1x/4–6 weeks
	Mixed testosterone esters	Climacteron^a	Oil solution	150 mg 1x/4–8 weeks
		Omnadren, Sustanon	Oil solution	50–100 mg 1x/4–6 weeks
	Nandrolone decanoate	Deca-Durabolin	Oil solution	25–50 mg 1x/6–12 weeks
	Prasterone enanthate^a	Gynodian Depot	Oil solution	200 mg 1x/4–6 weeks
Implant	Testosterone	Testopel	Pellet	50–100 mg 1x/3–6 months
Notes: Premenopausal women produce about 230 ± 70 μg testosterone per day (6.4 ± 2.0 mg testosterone per 4 weeks), with a range of 130 to 330 μg per day (3.6–9.2 mg per 4 weeks). Footnotes: ^a = Mostly discontinued or unavailable. ^b = Over-the-counter. Sources: See template.

Estradiol cypionate /
testosterone enanthate

Estradiol cypionate (top) and testosterone enanthate (bottom)
Combination of
Estradiol cypionate	Estrogen
Testosterone enanthate	Androgen; Anabolic steroid
Clinical data
Trade names	Supligol
Other names	EC/TE
Routes of administration	Intramuscular injection

See also

• List of combined sex-hormonal preparations

References

1. Vademecum de bolsillo: guía de especialidades medicinales : con índice terapéutico actualizado (enfermedades y síntomas de urgencia). Editorial Celcius - J.J. Vallory. 1976. SUPLIGOL (Ampollas) Comp. Testosterona enantato 80 mg (-= Testosterona 57,5 mg) y Estradiol ciclopentil-propionato, 4 mg. — Indic. Climaterio y sus trastornos, hipertrofia de la próstata, osteoporosis, supresión de la lactancia, etc. — Doslf. Climaterio: 1 ampolla por via I.M. cada 3-6 semanas, segun el caso. Osteoporosis: 1 ampolla cada 3 semanas. Supresion de la lactancia: 1 ampolla despues del parto.
2. https://www.drugs.com/international/supligol.html