Estradiol benzoate/progesterone/testosterone propionate

Estradiol benzoate/progesterone/testosterone propionate (EB/P4/TP), sold under the brand names Lukestra, Steratrin, Trihormonal, and Trinestryl, is an injectable combination medication of estradiol benzoate (EB), an estrogen, progesterone (P4), a progestogen, and testosterone propionate (TP), an androgen/anabolic steroid.[1][2][3][4][5] It contained 1 to 3 mg EB, 20 to 25 mg P4, and 25 mg TP, was provided in the form of ampoules, and was administered by intramuscular injection.[1][2][3][4][6] The medication was introduced by 1949 and was marketed in the United States, the United Kingdom, and Germany among other places.[7][8][5] It is no longer available.[9][10]

EB/P4/TP
Combination of
Estradiol benzoateEstrogen
ProgesteroneProgestogen
Testosterone propionateAndrogen; Anabolic steroid
Clinical data
Trade namesLukestra, Steratrin, Trihormonal, Trinestryl
Other namesEB/P4/TP
Routes of
administration		Intramuscular injection

See also

References
  1. Nowakowski H (9 March 2013). Hormone und Psyche die Endokrinologie des Alternden Menschen: Fünftes Symposion der Deutschen Gesellschaft für Endokrinologie Freiburg (Breisgau), den 7. bis 9. März 1957. Springer-Verlag. pp. 55–. ISBN 978-3-642-87014-9.
  2. Hager HH, Kern W, List PH, Roth HJ (29 July 2013). Hagers Handbuch der Pharmazeutischen Praxis: Für Apotheker, Arzneimittelhersteller, Ärzte und Medizinalbeamte: Wirkstoffgruppen II Chemikalien und Drogen (A-AL). Springer-Verlag. pp. 187–. ISBN 978-3-662-25655-8.
  3. Walther K, Auterhoff H, Neuwald F, Schmid W (9 March 2013). Hagers Handbuch der Pharmazeutischen Praxis: Für Apotheker, Arzneimittelhersteller, Drogisten, Ärzte und Medizinalbeamte. Springer-Verlag. pp. 1163–. ISBN 978-3-642-49759-9.
  4. Ufer J (1960). Hormontherapie in der Frauenheilkunde: Grundlagen und Praxis. de Gruyter. p. 155. ISBN 9783111138770.
  5. Bishop PM (1962). Chemistry of the Sex Hormones. Thomas. p. 85. Lukestra Injection Steroid Triad (oestradiol benz., test. prop. and progesterone) Merck, Sharp & Dohme
  6. Greenblatt RB, Barfield WE (January 1952). "Hormonal control of functional uterine bleeding". Am. J. Obstet. Gynecol. 63 (1): 153–7. doi:10.1016/s0002-9378(16)38992-x. PMID 14894511. S2CID 6863371. The estrogen-progesterone-testosterone combinations used in our studies were supplied by the following pharmaceutical companies: Wyeth, Inc.: Tristerone (6 mg. estrone, 50 mg. progesterone, 25 mg. testosterone). Schering Corporation: Steratrin (1 mg. estradiol benzoate, 25 mg. progesterone, 25 mg. testoterone propionate).Sharp and Dohme, Inc.: Lukestra (1.66 mg. estradiol benzoate, 25 mg. progesterone, 25 mg. testosterone propionate).
  7. United States. Patent Office (1950). Official Gazette of the United States Patent Office. U.S. Patent Office. pp. 31–.
  8. Unlisted Drugs. Unlisted Drugs Committee of the Pharmaceutical Section, Science-Technology Group, Special Libraries Association. 1952. Lukestra C. each cc, contains: estradiol benzoate, 1.67 mg.; progesterone, 25 mg.; and testosterone propionate, 25 mg.
  9. "?". IBM Watson Health.
  10. "Estradiol". Drugs.com.



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