Emanuel Rubin

Emanuel Rubin (born December 5, 1928) is an American pathologist known for his contributions to the study of liver disease, cardiomyopathy and alcoholic tissue injury, and as the editor of Rubin’s Pathology, a medical textbook first published in 1988, now in its eighth edition.[1][2]

Emanuel Rubin
Born
Emanuel Rubin

(1928-12-05) December 5, 1928
Brooklyn, New York, United States
NationalityUnited States
Alma mater
Known for
  • Pathology research and Education
  • Alcoholic tissue damage
  • Liver and heart disease
Scientific career
Fields
Institutions
  • Villanova University, PA
  • Harvard University
  • Medical School, MA
  • Mt. Sinai School of
  • Medicine, NY
  • Drexel University
  • Medical School, PA
  • Thomas Jefferson University, PA

Early life and education

Rubin obtained a B.S. degree from Villanova University in 1950, and an M.D. degree from Harvard Medical School in 1954. He served as an officer in the U.S. Navy from 1955 to 1957. Subsequently, he trained in pathology at the Mount Sinai Hospital from 1958 to 1962.

Career

Rubin joined the attending staff of Mt. Sinai Hospital in 1962.  He was appointed Professor of Pathology in 1968, and Chairman of the Department in 1972, at Mt. Sinai School of Medicine. In 1977, he moved to Philadelphia, where he was Chairman of Pathology at Drexel University Medical School. In 1986, he transferred to the Jefferson Medical College at Thomas Jefferson University. He was also appointed Adjunct Professor of Biochemistry and Biophysics at the University of Pennsylvania School of Medicine in 1987. In 2004, Rubin was named Distinguished Professor of Pathology, Anatomy and Cell Biology and Chairman Emeritus of the Jefferson Department[3]

Rubin has authored numerous original contributions in the fields of liver disease, cardiomyopathy and alcoholic tissue injury.[4] His work has been based on clinical studies of patients, volunteers and laboratory investigations of the effects of alcohol on cells and organs. Rubin originally demonstrated that primary biliary cirrhosis is an inflammatory lesion of bile ducts. His early work refuted concept that liver disease in alcoholics is caused by nutritional deficiencies, which led to the erroneous term “nutritional cirrhosis”. In rodents, sub-human primates and human volunteers he showed that excessive alcohol consumption is toxic to the liver independent of nutritional factors, a fact that serve as the basis of alcohol research today. Subsequently, Rubin and colleagues demonstrated the profound effects of alcohol on cell membranes, mitochondria, and other cell constituents. In a series of papers, together with co-workers in Spain, he determined that (1) alcoholic cardiomyopathy correlated with the lifetime dose of alcohol, (2) women were more susceptible to the cardiac effects of alcohol, and (3) alcoholic liver and heart diseases occurred concurrently.

Rubin is the founder and editor of Rubin’s Pathology, a textbook first published in 1988, now in its eight edition.[5][1][2]

Awards and honors
  • American Medical Writer's Award for Best Medical Textbook of the Year, 1989[6]
  • Doctor Honoris Causa, University of Barcelona, Spain, 1994[7]
  • The F.K. Mostofi Distinguished Service Award of U.S.-Canadian Academy of Pathology, 1996[8]
  • National Institutes of Health (NIH) MERIT Award, Bethesda, MD, 1996-2006
  • Tom Kent Award for Excellence in Pathology Education, Group for Research in Pathology Education (GRIPE), 2001[9]
  • Distinguished Service Award, Association of Pathology Chairs, 2006[10]
  • Gold Medal Award, International Academy of Pathology, 2006[11]
  • Gold-headed Cane Award (research), American Society for Investigative Pathology, 2006[12]
  • Lifetime Achievement Award, Research Society on Alcoholism, 2015[13]
  • Robbins Distinguished Educator Award, American Society for Investigative Pathology, 2018[14]
  • Doctor Honoris Causa, Republic of Italy, 2003
  • Lifetime Scientific Achievement Award, Sbarro Health Research Organization, 2004
  • Honorary Distinguished Member of Faculty Award, The Hebrew University of Jerusalem, 2020[15]

Selected publications
  • Advances in the biology of disease.  Rubin, E. and Damjanov. I., eds., Williams & Wilkins, Baltimore, Md., 1984.[16]
  • Alcohol and the cell, Rubin, E., Ed., Ann. NY Acad. Sci., New York, Vol. 492, 1987.[17]
  • Rubin's pathology, Editions 1–8, Lippincott-Williams and Wilkins, 1988–2015.[18]
  • Pathology reviews, 1989, Rubin, E. and Damjanov, I., eds., Humana Press, Clifton, N.J., 1989.[19]
  • Pathology: a study guide, Damjanov, I. and Rubin, E.: J.B. Lippincott Co.,  Philadelphia, Pa., 1990, 1995.[20]
  • Essentials of Rubin's pathology, Editions 1–6, Lippincott-Williams and Wilkins, 1990–2014.[21]
  • Molecular and cellular mechanisms of alcohol and anesthetics. Rubin, E., Miller, K.W. and Roth, S.H., eds., Ann. New York Academy of Sciences, New York, Vol. 625, 1991.[22]
  • Review of pathology. Damjanov, I. and Rubin, E.: J.B. Lippincott Co., Philadelphia, Pa., 1994.[23]
  • Pathology study guide: learning objectives with short answers.  Damjanov, I., Fenderson B.A., Rubin, E. eds., Thomas Jefferson University, Philadelphia, PA, 1997.[24]
  • Illustrated Q & A review of Rubin's pathology.  2nd ed., Fenderson, D.A., Strayer, D.S., Rubin, R. and Rubin, E., Lippincott-Williams and Wilkins, 2011.[25]
  • Principles of Rubin's pathology, 7th Ed., Rubin, E. and Reisner, H. Ed., Lippincott-Williams and Wilkins, 2018.[26]

References
  1. Reisner, Howard (April 15, 2013). Essentials of Rubin's Pathology. Lippincott Williams & Wilkins. ISBN 9781451181326.
  2. Rubin's Pathology: Mechanisms of Human Disease Eighth, North American Edition by Dr. David S. Strayer MD PhD (Editor), Dr. Jeffrey E. Saffitz MD PhD (Editor), Emanuel Rubin MD (Consultant Editor). ISBN 1496386140.
  3. "Emanuel Rubin, MD". Thomas Jefferson University. Retrieved June 20, 2018.
  4. pubmeddev (1975). "Rubin E[Author] alcohol - PubMed - NCBI". Biochemical and Biophysical Research Communications. 66 (4): 1349–56. doi:10.1016/0006-291x(75)90508-2. PMID 5.
  5. "Amazon.com: Rubin's Pathology: Clinicopathologic Foundations of Medicine (Pathology (Rubin)) eBook: David S. Strayer, Emanuel Rubin, David S. Strayer MD PhD, Emanuel Rubin MD: Kindle Store". www.amazon.com. Retrieved June 14, 2018.
  6. "Emanuel Rubin". The Pathologist. Retrieved January 8, 2019.
  7. ub (October 8, 2009). "Universitat de Barcelona - Rubin, Emanuel". www.ub.edu (in Catalan). Retrieved August 7, 2018.
  8. "The F.K. Mostofi Distinguished Service Award". www.uscap.org. Retrieved August 7, 2018.
  9. jkhewett. "Tom Kent Award for Excellence in Pathology Education". Retrieved August 7, 2018.
  10. Norman, Jen. "APC Distinguished Service Award | Association of Pathology Chairs". www.apcprods.org. Retrieved June 14, 2018.
  11. "Writing the Book on Pathology". The Pathologist. Retrieved June 14, 2018.
  12. "ASIP.org - Awards & Honors". www.asip.org. Retrieved June 14, 2018.
  13. "Annual Awards". www.rsoa.org. Retrieved June 14, 2018.
  14. "ASIP.org - Awards & Honors". www.asip.org. Retrieved June 14, 2018.
  15. "Emanuel Rubin". American Friends of Hebrew University. Retrieved January 19, 2021.
  16. "Books received". Cell. 40 (1): 8. January 1985. doi:10.1016/0092-8674(85)90302-2. ISSN 0092-8674. S2CID 54385428.
  17. Alcohol and the cell. Rubin, Emanuel, 1928-, New York Academy of Sciences., National Institute on Alcohol Abuse and Alcoholism (U.S.). New York, N.Y.: New York Academy of Sciences. 1987. ISBN 978-0897663793. OCLC 15366885.CS1 maint: others (link)
  18. Strayer, David S; Rubin, Emanuel; Saffitz, Jeffrey E; Schiller, Alan L (July 25, 2014). Rubin's pathology : clinicopathologic foundations of medicine. Strayer, David S. (David Sheldon), 1949-, Rubin, Emanuel, 1928-, Saffitz, Jeffrey E.; Schiller, Alan L. (Seventh ed.). Philadelphia. ISBN 9781451183900. OCLC 878915189.
  19. Roche, William R. (April 1992). "Pathology reviews 1989 and 1990. E. Rubin and I. Damjanov, eds., Humana Press, Clifton, NJ, 1989 and 1990. No. of pages: 299 and 255. Price: £63.20 per volume. ISBN: 0 89603 162 4 and 0 89603 195 0". The Journal of Pathology. 166 (4): 421–422. doi:10.1002/path.1711660419. ISSN 0022-3417.
  20. Wick, Mark R. (May 1, 1990). "Pathology: A Study Guide". American Journal of Clinical Pathology. 93 (5): 717.1–720. doi:10.1093/ajcp/93.5.717. ISSN 0002-9173.
  21. Essentials of Rubin's pathology. Rubin, Emanuel, 1928-, Reisner, Howard M. (6th ed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. 2014. ISBN 9781451110234. OCLC 793572239.CS1 maint: others (link)
  22. Molecular and cellular mechanisms of alcohol and anesthetics. Rubin, Emanuel, 1928-, Miller, Keith W., Roth, Sheldon H., New York Academy of Sciences., National Institute on Alcohol Abuse and Alcoholism (U.S.). New York, N.Y.: New York Academy of Sciences. 1991. ISBN 978-0897666619. OCLC 23868565.CS1 maint: others (link)
  23. Ivan., Damjanov (2000). Review of pathology. Rubin, Emanuel, 1928- (2nd ed.). Philadelphia: Lippincott Williams & Wilkins. ISBN 978-0397584086. OCLC 41476797.
  24. Ivan., Damjanov (1990). Pathology : a study guide. Rubin, Emanuel, 1928-. Philadelphia: J.B. Lippincott Co. ISBN 978-0397510108. OCLC 20535387.
  25. Lippincott's illustrated Q & A review of Rubin's pathology. Fenderson, Bruce A., Fenderson, Bruce A. (2nd ed.). Baltimore, MD: Lippincott Williams & Wilkins. 2011. ISBN 9781608316403. OCLC 642278669.CS1 maint: others (link)
  26. "Principles of Rubin's Pathology". shop.lww.com. Retrieved January 8, 2019.
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