Ekkehard Bautz

Ekkehard Karl Friedrich Bautz is a molecular biologist and chair of the Institute of Molecular Genetics at the University of Heidelberg.

Biography

He was born September 24, 1933 in Konstanz, Germany. After studying chemistry at Freiburg University and the University of Zürich, at the age of 26, he emigrated to the United States and later became a U.S. citizen. In 1961, he obtained a doctorate in molecular biology from the University of Wisconsin. He did postdoctoral work at the University of Illinois with a fellowship awarded by the Damon Runyon Memorial Fund for Cancer Research and in 1962 became an assistant professor at the Institute of Microbiology at Rutgers. In 1964, he participated in the Evolving Genes and Proteins Symposium, a landmark event in the history of molecular evolution research. In 1966, he was promoted to associate professor at the same institution. In 1970, he was appointed full professor there, but chose to return to Germany in the same year to become chair of the Institute of Molecular Genetics at the University of Heidelberg.[1]

Bautz's most important discovery is that of sigma factor, the first known transcription factor.[2]

Scientific work

He developed methods for the isolation of messenger RNA[3] and continued research on transcription. Later, he focused on novel selection methods, in particular phage display [4] and the generation of recombinant antibodies.[5]

In 1981, he founded the Center for Molecular Biology (ZMBH)[6] in Heidelberg, where he served as chair of microbiology and acting director from 1983 to 1985.[7]

Professional activities

Bautz was on the editorial board of the Journal of Virology[8] from 1966 to 1970, and of Molecular and General Genetics from 1971 to 2000. He was chairman of the German Genetics Society [9] from 1979 to 1981, and a board member of the German Cancer Research Centre [10] from 1978 to 1983. In 1994, he was appointed a board member of the Zentralkommission für Biologische Sicherheit (ZKBS, engl.: Central Commission for Biological Safety), advising the German government on the biological safety of genetically engineered organisms. He retired from the commission in 2000.

In 1983, he founded Progen GmbH, a biotech startup,[11] with Werner Franke and two other scientists from Heidelberg. He is also a cofounder of Peptide Specialty Laboratories (PSL) [12] and acted as general manager of Multimetrix GmbH from 2002 to 2007.

Awards and honours
  • Research Career Development Award, U.S. Public Health Service (1966-1970)
  • American Chemical Society Award in Enzyme Chemistry (Pfizer Award, 1972)
  • Ferdinand Springer Lectureship of the Federation of European Biochemical Societies (1973)
  • Heidelberg Academy of Sciences, elected member (1977)[13]
  • Waksman Medal of Rutgers University (USA) (1999)
  • University Medal, Heidelberg University (2000)

References
  1. "RE-EMIGRATION : Kommen sie? - DER SPIEGEL 46/1970". www.spiegel.de.
  2. Burgess RR, Travers AA, Dunn JJ, Bautz EK: Factor stimulating transcription by RNA polymerase. Nature 1969, 221(5175):43-46).
  3. Bautz EK, Hall BD: The isolation of T4-specific RNA on a DNA-cellulose column. Proc Natl Acad Sci 1962, 48:400-408
  4. Petersen G, Song D, Hugle-Dorr B, Oldenburg I, Bautz EK: Mapping of linear epitopes recognized by monoclonal antibodies with gene-fragment phage display libraries. Mol Gen Genet 1995, 249(4):425-431
  5. Liang M, Mahler M, Koch J, Ji Y, Li D, Schmaljohn C, Bautz EK: Generation of an HFRS patient-derived neutralizing recombinant antibody to Hantaan virus G1 protein and definition of the neutralizing domain. Journal of medical virology 2003, 69(1):99-107.
  6. "Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH)".
  7. Kiefer, Markus. "Fakultät für Biowissenschaften - Ruprecht-Karls-Universität Heidelberg". Heidelberg University – Heidelberg University (in German). Retrieved 2020-08-10.
  8. "Virology" – via www.journals.elsevier.com.
  9. "Welcome to German Genetics Society". gfgenetik1s Jimdo-Page!.
  10. "Archived copy". Archived from the original on 2006-02-18. Retrieved 2019-12-06.CS1 maint: archived copy as title (link)
  12. "Home". Home.
  13. "Heidelberger Akademie der Wissenschaften". www.haw.uni-heidelberg.de.
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