ESCO1

Establishment of sister chromatid cohesion N-acetyltransferase 1 is a protein that in humans is encoded by the ESCO1 gene.[5]

ESCO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4MXE
Identifiers
Aliases	ESCO1, A930014I12Rik, CTF, ECO1, EFO1, ESO1, establishment of sister chromatid cohesion N-acetyltransferase 1
External IDs	OMIM: 609674 MGI: 1925055 HomoloGene: 62166 GeneCards: ESCO1
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q11.2 Start 21,529,284 bp[1] End 21,600,884 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 10,566,507 bp[2] End 10,610,352 bp[2]
Gene ontology Molecular function • transferase activity • transferase activity, transferring acyl groups • metal ion binding • N-acetyltransferase activity • zinc ion binding • peptide-lysine-N-acetyltransferase activity • identical protein binding • acetyltransferase activity Cellular component • chromatin • cell nucleus • nucleoplasm • chromosome Biological process • post-translational protein acetylation • cell cycle • sister chromatid cohesion • regulation of DNA replication • peptidyl-lysine acetylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114799	77805
Ensembl	ENSG00000141446	ENSMUSG00000024293
UniProt	Q5FWF5	Q69Z69
RefSeq (mRNA)	NM_052911	NM_001081222 NM_144542
RefSeq (protein)	NP_443143	NP_001074691
Location (UCSC)	Chr 18: 21.53 – 21.6 Mb	Chr 18: 10.57 – 10.61 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

ESCO1 belongs to a conserved family of acetyltransferases involved in sister chromatid cohesion.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000141446 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024293 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Establishment of sister chromatid cohesion N-acetyltransferase 1". Retrieved 2015-09-17.
6. Hou F, Zou H (2005). "Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion". Molecular Biology of the Cell. 16 (8): 3908–18. doi:10.1091/mbc.E04-12-1063. PMC 1182326. PMID 15958495.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human N-acetyltransferase ESCO1

This article incorporates text from the United States National Library of Medicine, which is in the public domain.