ELAC1

Zinc phosphodiesterase ELAC protein 1 is an enzyme that in humans is encoded by the ELAC1 gene.[5][6]

ELAC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3ZWF
Identifiers
Aliases	ELAC1, D29, elaC ribonuclease Z 1
External IDs	OMIM: 608079 MGI: 1890495 HomoloGene: 10272 GeneCards: ELAC1
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q21.2 Start 50,967,991 bp[1] End 50,988,121 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E2 Start 73,735,038 bp[2] End 73,754,479 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nuclease activity • endonuclease activity • 3'-tRNA processing endoribonuclease activity • hydrolase activity • metal ion binding • endoribonuclease activity, producing 5'-phosphomonoesters Cellular component • cytoplasm • cytosol • cell nucleus Biological process • tRNA 3'-trailer cleavage • RNA phosphodiester bond hydrolysis, endonucleolytic • tRNA processing • tRNA 3'-trailer cleavage, endonucleolytic Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55520	114615
Ensembl	ENSG00000141642	ENSMUSG00000036941
UniProt	Q9H777	Q8VEB6
RefSeq (mRNA)	NM_018696	NM_053255
RefSeq (protein)	NP_061166	NP_444485
Location (UCSC)	Chr 18: 50.97 – 50.99 Mb	Chr 18: 73.74 – 73.75 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000141642 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036941 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Takaku H, Minagawa A, Takagi M, Nashimoto M (Apr 2003). "A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease". Nucleic Acids Res. 31 (9): 2272–8. doi:10.1093/nar/gkg337. PMC 154223. PMID 12711671.
6. "Entrez Gene: ELAC1 elaC homolog 1 (E. coli)".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yanaihara N, Kohno T, Takakura S, et al. (2001). "Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus". Genomics. 72 (2): 169–79. doi:10.1006/geno.2000.6454. PMID 11401430.
• Tavtigian SV, Simard J, Teng DH, et al. (2001). "A candidate prostate cancer susceptibility gene at chromosome 17p". Nat. Genet. 27 (2): 172–80. doi:10.1038/84808. PMID 11175785. S2CID 7889550.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.