EIF3CL

Eukaryotic translation initiation factor 3 subunit C like is a protein that in humans is encoded by the EIF3CL gene. [3]

EIF3CL
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3J8B, 3J8C
Identifiers
Aliases	EIF3CL, eukaryotic translation initiation factor 3 subunit C like
External IDs	GeneCards: EIF3CL
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.1 Start 28,379,579 bp[1] End 28,403,879 bp[1]
Gene ontology Molecular function • translation initiation factor binding • translation initiation factor activity • RNA binding Cellular component • cytoplasm • eukaryotic translation initiation factor 3 • eukaryotic 43S preinitiation complex • eukaryotic 48S preinitiation complex Biological process • translational initiation • protein biosynthesis • formation of cytoplasmic translation initiation complex • cytoplasmic translational initiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	728689	n/a
Ensembl	ENSG00000205609	n/a
UniProt	B5ME19	n/a
RefSeq (mRNA)	NM_001099661 NM_001317856 NM_001317857	n/a
RefSeq (protein)	NP_001093131 NP_001304785 NP_001304786	n/a
Location (UCSC)	Chr 16: 28.38 – 28.4 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Function

The protein encoded by this gene is a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex. The encoded protein is nearly identical to another protein, eIF3c, from a related gene. The eIF3 complex binds the 40S ribosome and mRNAs to enable translation initiation. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015].

See also

• Eukaryotic initiation factor 3 (eIF3)

References

1. GRCh38: Ensembl release 89: ENSG00000205609 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: Eukaryotic translation initiation factor 3 subunit C like". Retrieved 2020-04-15.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.