EDEM3

ER degradation-enhancing alpha-mannosidase-like 3 is an enzyme that in humans is encoded by the EDEM3 gene.[5][6][7]

EDEM3
Identifiers
Aliases	EDEM3, C1orf22, ER degradation enhancing alpha-mannosidase like protein 3
External IDs	OMIM: 610214 MGI: 1914217 HomoloGene: 11866 GeneCards: EDEM3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.3 Start 184,690,237 bp[1] End 184,754,907 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 G1-G2 Start 151,755,371 bp[2] End 151,822,051 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • hydrolase activity • metal ion binding • mannosyl-oligosaccharide 1,2-alpha-mannosidase activity • catalytic activity Cellular component • endoplasmic reticulum lumen • endoplasmic reticulum • membrane • endoplasmic reticulum quality control compartment Biological process • endoplasmic reticulum unfolded protein response • protein glycosylation • N-glycan processing • response to unfolded protein • glycoprotein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process • mannose trimming involved in glycoprotein ERAD pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80267	66967
Ensembl	ENSG00000116406	ENSMUSG00000043019
UniProt	Q9BZQ6	Q2HXL6
RefSeq (mRNA)	NM_025191 NM_001319960	NM_001039644 NM_001311165 NM_001311166
RefSeq (protein)	NP_001306889 NP_079467	NP_001034733 NP_001298094 NP_001298095
Location (UCSC)	Chr 1: 184.69 – 184.75 Mb	Chr 1: 151.76 – 151.82 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000116406 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043019 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW (Mar 2005). "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins". Glycobiology. 15 (4): 421–36. doi:10.1093/glycob/cwi014. PMID 15537790.
6. Olivari S, Galli C, Alanen H, Ruddock L, Molinari M (Jan 2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J Biol Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.
7. "Entrez Gene: EDEM3 ER degradation enhancer, mannosidase alpha-like 3".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Sood R, Bonner TI, Makalowska I, et al. (2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Hirao K, Natsuka Y, Tamura T, et al. (2006). "EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming". J. Biol. Chem. 281 (14): 9650–8. doi:10.1074/jbc.M512191200. PMID 16431915.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.