ECT2L

Epithelial cell transforming sequence 2 oncogene-like is a protein that in humans is encoded by the ECT2L gene.[4]

ECT2L
Identifiers
Aliases	ECT2L, ARHGEF32, C6orf91, FBXO49, LFDH, dJ509I19.2, dJ509I19.3, dJ509I19.5, epithelial cell transforming 2 like
External IDs	MGI: 3641723 HomoloGene: 46005 GeneCards: ECT2L
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q24.1 Start 138,795,911 bp[1] End 138,904,070 bp[1]
Orthologs
Species	Human	Mouse
Entrez	345930	100045792
Ensembl	ENSG00000203734	ENSMUSG00000071392
UniProt	Q008S8	n/a
RefSeq (mRNA)	NM_001077706 NM_001195037	NM_001195036 NM_001370991
RefSeq (protein)	NP_001071174 NP_001181966	n/a
Location (UCSC)	Chr 6: 138.8 – 138.9 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Clinical relevance

Recurrent mutations of this gene have been associated to cases of acute lymphoblastic leukaemia.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000203734 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: Epithelial cell transforming sequence 2 oncogene-like". Retrieved 2012-02-19.
5. Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen SC, Wei L, Collins-Underwood JR, Ma J, Roberts KG, Pounds SB, Ulyanov A, Becksfort J, Gupta P, Huether R, Kriwacki RW, Parker M, McGoldrick DJ, Zhao D, Alford D, Espy S, Bobba KC, Song G, Pei D, Cheng C, Roberts S, Barbato MI, Campana D, Coustan-Smith E, Shurtleff SA, Raimondi SC, Kleppe M, Cools J, Shimano KA, Hermiston ML, Doulatov S, Eppert K, Laurenti E, Notta F, Dick JE, Basso G, Hunger SP, Loh ML, Devidas M, Wood B, Winter S, Dunsmore KP, Fulton RS, Fulton LL, Hong X, Harris CC, Dooling DJ, Ochoa K, Johnson KJ, Obenauer JC, Evans WE, Pui CH, Naeve CW, Ley TJ, Mardis ER, Wilson RK, Downing JR, Mullighan CG (2012). "The genetic basis of early T-cell precursor acute lymphoblastic leukaemia". Nature. 481 (7380): 157–163. Bibcode:2012Natur.481..157Z. doi:10.1038/nature10725. PMC 3267575. PMID 22237106.

Further reading