Dp-1 holin family

The Bacterophase Dp-1 Holin (Dp-1 Holin) Family (TC# 1.E.24) is a family of proteins present in several Gram-positive bacteria (i.e., Enterococcus faecalis) and their phage.[1][2] The genes coding for the lytic system of the pneumococcal phage, Dp-1, has been cloned and characterized.[3] The holin of phage Dp-1 is 74 amino acyl residues (aas) long with two putative transmembrane segments (TMSs) (residues 12-32 and 39-57). The lytic enzyme of Dp-1 (Pal), an N-acetyl-muramoyl-L-alanine amidase, shows a modular organization similar to that described for the lytic enzymes of Streptococcus pneumoniae and its bacteriophage in which change in the order of the functional domains changes the enzyme specificity.[2] A representative list of proteins belonging to the Dp-1 family can be found in the Transporter Classification Database.[4]

See also

References
  1. Labrie, Steve; Vukov, Natasa; Loessner, Martin J.; Moineau, Sylvain (2004-04-01). "Distribution and composition of the lysis cassette of Lactococcus lactis phages and functional analysis of bacteriophage ul36 holin". FEMS Microbiology Letters. 233 (1): 37–43. doi:10.1016/j.femsle.2004.01.038. ISSN 0378-1097. PMID 15043867.
  2. Paulsen, I. T.; Banerjei, L.; Myers, G. S. A.; Nelson, K. E.; Seshadri, R.; Read, T. D.; Fouts, D. E.; Eisen, J. A.; Gill, S. R. (2003-03-28). "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis". Science. 299 (5615): 2071–2074. Bibcode:2003Sci...299.2071P. doi:10.1126/science.1080613. ISSN 1095-9203. PMID 12663927. S2CID 45480495.
  3. Sheehan, M. M.; García, J. L.; López, R.; García, P. (1997-08-01). "The lytic enzyme of the pneumococcal phage Dp-1: a chimeric lysin of intergeneric origin". Molecular Microbiology. 25 (4): 717–725. doi:10.1046/j.1365-2958.1997.5101880.x. ISSN 0950-382X. PMID 9379901. S2CID 37991956.
  4. "1.E.24 The Bacterophase Dp-1 Holin (Dp-1 Holin) Family". Transporter Classification Database. Retrieved 2016-03-28.

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