Dolichol O-acyltransferase

In enzymology, a dolichol O-acyltransferase (EC 2.3.1.123) is an enzyme that catalyzes the chemical reaction

palmitoyl-CoA + dolichol CoA + dolichyl palmitate
dolichol O-acyltransferase
Identifiers
EC number2.3.1.123
CAS number111839-04-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are palmitoyl-CoA and dolichol, whereas its two products are CoA and dolichyl palmitate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is palmitoyl-CoA:dolichol O-palmitoyltransferase. This enzyme is also called acyl-CoA:dolichol acyltransferase.

References

    • Tollbom O, Valtersson C, Chojnacki T, Dallner G (1988). "Esterification of dolichol in rat liver". J. Biol. Chem. 263 (3): 1347–52. PMID 3121628.


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