Demethylmenaquinone methyltransferase
Demethylmenaquinone methyltransferase (EC 2.1.1.163, S-adenosyl-L-methionine-DMK methyltransferase, demethylmenaquinone C-methylase, 2-heptaprenyl-1,4-naphthoquinone methyltransferase, 2-demethylmenaquinone methyltransferase, S-adenosyl-L-methionine:2-demethylmenaquinone methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:demethylmenaquinone methyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- demethylmenaquinol + S-adenosyl-L-methionine menaquinol + S-adenosyl-L-homocysteine
| Demethylmenaquinone methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.163 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme catalyses the last step in menaquinone biosynthesis.
References
- Koike-Takeshita A, Koyama T, Ogura K (May 1997). "Identification of a novel gene cluster participating in menaquinone (vitamin K2) biosynthesis. Cloning and sequence determination of the 2-heptaprenyl-1,4-naphthoquinone methyltransferase gene of Bacillus stearothermophilus". The Journal of Biological Chemistry. 272 (19): 12380–3. doi:10.1074/jbc.272.19.12380. PMID 9139683.
- Wissenbach U, Ternes D, Unden G (1992). "An Escherichia coli mutant containing only demethylmenaquinone, but no menaquinone: effects on fumarate, dimethylsulfoxide, trimethylamine N-oxide and nitrate respiration". Archives of Microbiology. 158 (1): 68–73. doi:10.1007/BF00249068. PMID 1444716.
- Catala F, Azerad R, Lederer E (1970). "[Properties of demethylmenaquinone C-methylase from Mycobacterium phlei]". Internationale Zeitschrift für Vitaminforschung. International Journal of Vitamin Research. Journal International de Vitaminologie. 40 (3): 363–73. PMID 5450997.
- Lee PT, Hsu AY, Ha HT, Clarke CF (March 1997). "A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene". Journal of Bacteriology. 179 (5): 1748–54. doi:10.1128/jb.179.5.1748-1754.1997. PMC 178890. PMID 9045837.
External links
- Demethylmenaquinone+methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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