De Los Santos
De Los Santos is a Spanish surname meaning "of the saints". Notable people with the surname include:
- Abel De Los Santos (born 1992), American baseball player
- Alejandro de los Santos (1902–1982), Argentinian football player
- Epifanio de los Santos (1871–1928), Filipino historian
- Fautino de los Santos (born 1986), Dominican Republic baseball player
- Gonzalo de los Santos (born 1976), Uruguayan football player
- Jaime de los Santos (born 1946), Filipino general
- Ramón de los Santos (born 1949), Dominican Republic baseball player
- Valerio de los Santos (born 1972), Dominican Republic baseball player
- William de los Santos, (born 1964), actor
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