De Francesco
De Francesco (or de Francesco) is an Italian surname. Notable people with this surname include:
- Alberto De Francesco (born 1994), Italian football player
- Francesco De Francesco (born 1977), Italian football striker
- Matteuccia de Francesco (died 1428), an alleged Italian witch and nun
- Sebastian de Francesco (born 1981), Italian football striker
- Tony DeFrancesco (born 1963), American baseball coach
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