David R. Soll

David R. Soll (born April 29, 1942) is a Professor of Biology at the University of Iowa. He is best known for the motion analysis of living cells, the discovery of Candida albicans phenotypic switching and monoclonal antibody technology. He is the current director of the Developmental Studies Hybridoma Bank, Monoclonal Antibody Research Institute, and the WM Keck Dynamic Image Analysis Facility. He is also a member of the board of directors of the Foundation for Monoclonal Antibody Research. He is a Fellow of both the American Academy of Microbiology and the American Association for the Advancement of Science since 2006. He has published over 330 articles in various fields of biomedicine,[1] and has received more than 78 grants and contracts,[2] founded four companies, and is active on several editorial boards for major scientific publications.[3][4]

David R. Soll
Born (1942-04-02) April 2, 1942
Philadelphia, Pennsylvania, USA
Alma materUniversity of Wisconsin–Madison
Known forMotion analysis of living cells
monoclonal antibody technologies
Candida albicans
Awards
  • Roy J. and Lucille Carver/Emil Witschi Professorship of the Biological Sciences (1989)
  • Lucille K. George Medal (2009)
  • Rhoda Benham Award (2013)
  • Ian Murray Memorial Award from the British Society of Medical Mycology (1988, 2003)
Scientific career
InstitutionsThe University of Iowa
Developmental Studies Hybridoma Bank
WM Keck Dynamic Image Analysis Facility

Background

Soll was born in South Philadelphia, Pennsylvania and graduated from Central High School (Philadelphia) for Boys in 1959 with a BA. He then attended the University of Wisconsin from 1960 to 1969, receiving a BA, MS and PhD. He served as a post-doctoral fellow and taught Introductory Biology at Brandeis University. In 1972 he joined the Department of Biology at the University of Iowa as an Assistant Professor. In 1976 he became an Associate Professor and in 1982 a Full Professor. In 1989 he was awarded the Roy J. and Lucille Carver/Emil Witschi Professorship of the Biological Sciences, and in 1989 also became a Full Professor of Dentistry. In 2005, he was elected a Fellow of the American Association for the Advancement of Science (AAAS) and in 2006 a Fellow of the American Academy of Microbiology. In 2009 he was awarded the Lucille K. George Medal from the International Society of Human and Animal Mycology, and in 2013 he was awarded the Rhoda Benham Medal from the Medical Mycological Society of the Americas. David Soll was married for 30 years to Michele Morice and has three children, Jacob Soll, Samantha Soll and Benjamin Soll.

Career

From 1965 to 1970, he worked on the germination of Blastoclandiella emersonii under the mentorship of David Sonneborn and discovered that complex differentiations can be preprogrammed and occur without RNA or protein synthesis.[5] From 1972 to 1978, he and colleagues worked on the "accumulation and erasure of morphogenetics information" in Dictyostelium discoideum.[6] In 1979, he formulated the first model and conditional methods to analyze timer pathways in developing systems.[7] From 1977 to 1984, he developed pH-regulated dimorphism and applied it to study the regulation of the bud-hypha transition in Candida albicans[8] In 1985 and 1987, he and colleagues discovered the first high frequency switching system in the pathogenic yeast Candida albicans. Next to this phenotypic, morphological switching system he and his co-workers also discovered the epigenetic, phenotypic white to opaque switching system.[9][10] In 1989, he and Dr. E Voss finished and licensed the Dynamic Motion Analyses System (DMS), to Motion Analyses Corporation of Santa Rosa, CA. In 1997, Soll and Voss obtained the patent for DIAS,[11] the next generation of DMS. In 1992 Soll founded the company Solltech, Inc., a computer software and hardware development company to develop and distribute DIAS.[12] From 1987 to 1995, he and co-workers developed the first DNA fingerprinting probes for studying the population structure of infection fungi, and in 1995 received a patent for the software DENDRON, which analyzed DNA fingerprints.[13] In 1995, Soll formed the company Caviforce Technologies to develop a method of using ultrasound for seed germination. From 1995 to 2004, he and colleagues developed the first 3D Dynamic Image Analysis System (3D-DIAS) for cells and embryos, describing how embryos form and amoeboid cells crawl.[14][15] Ultrasound Solutions Inc., was formed in 1999 to develop the technology to use ultrasound in waste management.[16][17] In 2003 Soll founded the company Solltechnologies Inc., to sell DIAS and Dendron software. From 2005 to present, he and colleagues discovered that Candida albicans forms a "pathogenic" biofilm and a "sexual" biofilm, depending on the configuration of the mating type locus and identified the alternative pathways regulating each biofilm.[18] From 2011 to present, he and colleagues developed a 4D model for reconstructing and motion analysing cancer tumors, the formation of cancer tumors in 3D, and the software to reconstruct and motion analyze the 3D tumors.

Current Work

Soll is now the Director of the Developmental Studies Hybridoma Bank (DSHB), a NIH National Resource, Director of the W.M. Keck Dynamic Image Analysis Facility, Director of the Monoclonal Antibody Research Institute and on the board of the Foundation for Monoclonal Antibody Research. His research groups now focus on 1) the role of mating and switching in the pathogenesis of Candida albicans, 2) cell motility and the cytoskeleton, 3) advanced monoclonal antibody technology and 4) methods for suppressing tumorigenesis in cancer patients.

References
  1. https://www.researchgate.net/profile/David_Soll/publications
  2. http://projectreporter.nih.gov/reporter_SearchResults.cfm?icde=23446842
  3. "Editorial Board".
  4. "Cytoskeleton". doi:10.1002/(ISSN)1949-3592.
  5. Soll, D. R.; Sonneborn, D. R. (1971). "Zoospore germination in Blastocladiella emersonii: Cell differentiation without protein synthesis?". Proceedings of the National Academy of Sciences of the United States of America. 68 (2): 459–63. Bibcode:1971PNAS...68..459S. doi:10.1073/pnas.68.2.459. PMC 388960. PMID 5277101.
  6. Soll, D. R.; Waddell, D. R. (1975). "Morphogenesis in the slime mold Dictyostelium discoideum. 1. The accumulation and erasure of "morphogenetic information"". Developmental Biology. 47 (2): 292–302. doi:10.1016/0012-1606(75)90283-3. PMID 1239391.
  7. Soll, D. R. (1979). "Timers in developing systems". Science. 203 (4383): 841–9. Bibcode:1979Sci...203..841S. doi:10.1126/science.419408. PMID 419408.
  8. Soll, D. R.; Mitchell, L. H. (1983). "Filament ring formation in the dimorphic yeast Candida albicans". The Journal of Cell Biology. 96 (2): 486–93. doi:10.1083/jcb.96.2.486. PMC 2112305. PMID 6339518.
  9. Slutsky B, Staebell M, Anderson J, Risen L, Pfaller M, Soll DR (1987). ""White-opaque transition": a second high-frequency switching system in Candida albicans". J Bacteriol. 169 (1): 189–97. doi:10.1128/jb.169.1.189-197.1987. PMC 211752. PMID 3539914.
  10. Slutsky, B; Buffo, J; Soll, D. R. (1985). "High-frequency switching of colony morphology in Candida albicans". Science. 230 (4726): 666–9. Bibcode:1985Sci...230..666S. doi:10.1126/science.3901258. PMID 3901258.
  11. "Dynamic image analysis system".
  12. Soll, D. R. (1995). The use of computers in understanding how animal cells crawl. International Review of Cytology. 163. pp. 43–104. doi:10.1016/S0074-7696(08)62209-3. ISBN 9780123645678. PMID 8522423.
  13. Soll, D. R. (2000). "The ins and outs of DNA fingerprinting the infectious fungi". Clinical Microbiology Reviews. 13 (2): 332–70. doi:10.1128/cmr.13.2.332-370.2000. PMC 100156. PMID 10756003.
  14. Heid, P. J.; Voss, E; Soll, D. R. (2002). "3D-DIASemb: a computer-assisted system for reconstructing and motion analyzing in 4D every cell and nucleus in a developing embryo". Developmental Biology. 245 (2): 329–347. doi:10.1006/dbio.2002.0631. PMID 11977985.
  15. Soll, D. R.; Wessels, D; Kuhl, S; Lusche, D. F. (2009). "How a cell crawls and the role of cortical myosin II". Eukaryotic Cell. 8 (9): 1381–96. doi:10.1128/EC.00121-09. PMC 2747829. PMID 19633268.
  16. http://www.news-releases.uiowa.edu/2000/may/0526swineodor.html
  17. https://www.sciencedaily.com/releases/2000/05/000531072419.html
  18. Daniels, K. J.; Srikantha, T; Lockhart, S. R.; Pujol, C; Soll, D. R. (2006). "Opaque cells signal white cells to form biofilms in Candida albicans". The EMBO Journal. 25 (10): 2240–52. doi:10.1038/sj.emboj.7601099. PMC 1462973. PMID 16628217.
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