DRD1IP

Neuron-specific vesicular protein calcyon is a protein that in humans is encoded by the CALY gene.[5][6] Its alternative name is Calcyon.

CALY
Identifiers
Aliases	CALY, DRD1IP, NSG3, calcyon neuron specific vesicular protein
External IDs	OMIM: 604647 MGI: 1915816 HomoloGene: 9256 GeneCards: CALY
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.3 Start 133,324,072 bp[1] End 133,336,935 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F4 Start 140,069,880 bp[2] End 140,082,548 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • clathrin light chain binding • GO:0032403 macromolecular complex binding • cargo receptor activity Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • cytoplasmic vesicle membrane • cytoplasmic vesicle • membrane • endosome • postsynaptic endocytic zone • glutamatergic synapse Biological process • clathrin coat assembly • dopamine receptor signaling pathway • positive regulation of endocytosis • endocytosis • endosomal transport • postsynaptic neurotransmitter receptor internalization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50632	68566
Ensembl	ENSG00000130643	ENSMUSG00000025468
UniProt	Q9NYX4	Q9DCA7
RefSeq (mRNA)	NM_015722 NM_001321617	NM_001190385 NM_001190386 NM_026769
RefSeq (protein)	NP_001308546 NP_056537	NP_001177314 NP_001177315 NP_081045
Location (UCSC)	Chr 10: 133.32 – 133.34 Mb	Chr 7: 140.07 – 140.08 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with dopamine receptor D1 and may interact with other DA receptor subtypes and/or GPCRs.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000130643 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025468 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Heijtz RD, Alexeyenko A, Castellanos FX (July 2007). "Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD". Behavioral and Brain Functions. 3 (1): 33. doi:10.1186/1744-9081-3-33. PMC 1949817. PMID 17623072.
6. "Entrez Gene: DRD1IP dopamine receptor D1 interacting protein".

Further reading

• Milligan G, White JH (October 2001). "Protein-protein interactions at G-protein-coupled receptors". Trends in Pharmacological Sciences. 22 (10): 513–8. doi:10.1016/S0165-6147(00)01801-0. PMID 11583808.
• Ali MK, Bergson C (December 2003). "Elevated intracellular calcium triggers recruitment of the receptor cross-talk accessory protein calcyon to the plasma membrane". The Journal of Biological Chemistry. 278 (51): 51654–63. doi:10.1074/jbc.M305803200. PMID 14534309.
• Luo X, Kranzler H, Lappalainen J, Rosenheck R, Charney D, Zuo L, Erdos J, van Kammen DP, Gelernter J (February 2004). "CALCYON gene variation, schizophrenia, and cocaine dependence". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 125B (1): 25–30. doi:10.1002/ajmg.b.20092. PMID 14755439. S2CID 24881261.
• Laurin N, Misener VL, Crosbie J, Ickowicz A, Pathare T, Roberts W, Malone M, Tannock R, Schachar R, Kennedy JL, Barr CL (December 2005). "Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorder". Molecular Psychiatry. 10 (12): 1117–25. doi:10.1038/sj.mp.4001737. PMID 16172615.
• Xiao J, Dai R, Negyessy L, Bergson C (June 2006). "Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis". The Journal of Biological Chemistry. 281 (22): 15182–93. doi:10.1074/jbc.M600265200. PMID 16595675.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Kruusmägi M, Zelenin S, Brismar H, Scott L (October 2007). "Intracellular dynamics of calcyon, a neuron-specific vesicular protein". NeuroReport. 18 (15): 1547–51. doi:10.1097/WNR.0b013e3282f03f51. PMID 17885599. S2CID 24544827.