DOK3

Docking protein 3 is a protein that in humans is encoded by the DOK3 gene.[5][6][7]

DOK3
Identifiers
Aliases	DOK3, DOKL, docking protein 3
External IDs	OMIM: 611435 MGI: 1351490 HomoloGene: 8448 GeneCards: DOK3
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.3 Start 177,501,907 bp[1] End 177,511,274 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B1 Start 55,523,231 bp[2] End 55,529,296 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • membrane • cytoplasm • cell membrane • secretory granule membrane • ficolin-1-rich granule membrane Biological process • neutrophil degranulation • Ras protein signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79930	27261
Ensembl	ENSG00000146094	ENSMUSG00000035711
UniProt	Q7L591	Q9QZK7
RefSeq (mRNA)	NM_001144875 NM_001144876 NM_001308235 NM_001308236 NM_024872 NM_001375794 NM_001375795 NM_001375796 NM_001375797 NM_001375798 NM_001375799 NM_001384137 NM_001384138 NM_001384139	NM_013739
RefSeq (protein)	NP_001138347 NP_001138348 NP_001295164 NP_001295165 NP_079148 NP_001362723 NP_001362724 NP_001362725 NP_001362726 NP_001362727 NP_001362728 NP_001371066 NP_001371067 NP_001371068	NP_038767
Location (UCSC)	Chr 5: 177.5 – 177.51 Mb	Chr 13: 55.52 – 55.53 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000146094 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035711 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lemay S, Davidson D, Latour S, Veillette A (Apr 2000). "Dok-3, a Novel Adapter Molecule Involved in the Negative Regulation of Immunoreceptor Signaling". Mol Cell Biol. 20 (8): 2743–54. doi:10.1128/MCB.20.8.2743-2754.2000. PMC 85490. PMID 10733577.
6. Favre C, Gerard A, Clauzier E, Pontarotti P, Olive D, Nunes JA (Feb 2003). "DOK4 and DOK5: new Dok-related genes expressed in human T cells". Genes Immun. 4 (1): 40–5. doi:10.1038/sj.gene.6363891. PMID 12595900.
7. "Entrez Gene: DOK3 docking protein 3".

Further reading

• Cong F, Yuan B, Goff SP (2000). "Characterization of a Novel Member of the DOK Family That Binds and Modulates Abl Signaling". Mol. Cell. Biol. 19 (12): 8314–25. doi:10.1128/MCB.19.12.8314. PMC 84915. PMID 10567556.
• Grimm J, Sachs M, Britsch S, et al. (2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation" (PDF). J. Cell Biol. 154 (2): 345–54. doi:10.1083/jcb.200102032. PMC 2150770. PMID 11470823.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Robson JD, Davidson D, Veillette A (2004). "Inhibition of the Jun N-Terminal Protein Kinase Pathway by SHIP-1, a Lipid Phosphatase That Interacts with the Adaptor Molecule Dok-3". Mol. Cell. Biol. 24 (6): 2332–43. doi:10.1128/MCB.24.6.2332-2343.2004. PMC 355862. PMID 14993273.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Honma M, Higuchi O, Shirakata M, et al. (2007). "Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases". Genes Cells. 11 (2): 143–51. doi:10.1111/j.1365-2443.2006.00926.x. PMID 16436051. S2CID 42571721.