DNA damage-binding protein

damage-specific DNA binding protein 2, 48kDa
Identifiers
Symbol	DDB2
Alt. symbols	DBB, UV-DDB2, FLJ34321
NCBI gene	1643
HGNC	2718
OMIM	600811
RefSeq	NM_000107
UniProt	Q92466
Other data
Locus	Chr. 11 p12-p11
Search for
Structures	Swiss-model
Domains	InterPro

Search for
Structures	Swiss-model
Domains	InterPro

damage-specific DNA binding protein 1, 127kDa
Identifiers
Symbol	DDB1
Alt. symbols	XPE
NCBI gene	1642
HGNC	2717
OMIM	600045
RefSeq	NM_001923
UniProt	Q16531
Other data
Locus	Chr. 11 q12-q13
Search for
Structures	Swiss-model
Domains	InterPro

DNA damage-binding protein or UV-DDB[1] is a protein complex that is responsible for repair of UV-damaged DNA.[2] This complex is composed of two protein subunits, a large subunit DDB1 (p127) and a small subunit DDB2 (p48). When cells are exposed to UV radiation, DDB1 moves from the cytosol to the nucleus and binds to DDB2, thus forming the UV-DDB complex. This complex functions in nucleotide excision repair, recognising UV-induced (6-4) pyrimidine-pyrimidone photoproducts and cyclobutane pyrimidine dimers.[1]

References

Iovine, Barbara; Iannella, Maria Luigia; Bevilacqua, Maria Assunta (2011). "Damage-specific DNA binding protein 1 (DDB1): a protein with a wide range of functions". The International Journal of Biochemistry & Cell Biology. Elsevier. 43 (12): 1664–1667. doi:10.1016/j.biocel.2011.09.001. PMID 21959250.
Dualan R, Brody T, Keeney S, Nichols AF, Admon A, Linn S (Feb 1996). "Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein". Genomics. 29 (1): 62–9. doi:10.1006/geno.1995.1215. PMID 8530102.

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[Iovine2011-1] Iovine, Barbara; Iannella, Maria Luigia; Bevilacqua, Maria Assunta (2011). "Damage-specific DNA binding protein 1 (DDB1): a protein with a wide range of functions". The International Journal of Biochemistry & Cell Biology. Elsevier. 43 (12): 1664–1667. doi:10.1016/j.biocel.2011.09.001. PMID 21959250.

[pmid8530102-2] Dualan R, Brody T, Keeney S, Nichols AF, Admon A, Linn S (Feb 1996). "Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein". Genomics. 29 (1): 62–9. doi:10.1006/geno.1995.1215. PMID 8530102.