DLK1

Protein delta homolog 1 is a protein that in humans is encoded by the DLK1 gene.[4][5][6]

DLK1
Identifiers
AliasesDLK1, DLK, DLK-1, Delta1, FA1, PREF1, Pref-1, ZOG, pG2, AW742678, DlkI, Ly107, Peg9, SCP1, delta like non-canonical Notch ligand 1
External IDsOMIM: 176290 MGI: 94900 HomoloGene: 2846 GeneCards: DLK1
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q32.2Start100,725,705 bp[1]
End100,738,224 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8788

13386

Ensembl

ENSG00000185559

ENSMUSG00000040856

UniProt

P80370

Q09163

RefSeq (mRNA)

NM_001032997
NM_003836
NM_001317172

NM_001190703
NM_001190704
NM_001190705
NM_010052

RefSeq (protein)

NP_001304101
NP_003827
NP_003827.3

NP_001177632
NP_001177633
NP_001177634
NP_034182

Location (UCSC)Chr 14: 100.73 – 100.74 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

It is expressed as a transmembrane protein, but a soluble form cleaved off by ADAM17 is active in inhibiting adipogenesis,[7] the differentiation of pre-adipocytes into adipocytes.[8]

It is a member of the EGF-like family of homeotic proteins.[9]

Part of the Dlk1-DIO3 imprinting control region, this gene is one involved in the epigenetic process that causes a subset of genes to be regulated based on their parental origin.[10]

Such imprinted genes are required for the formation of the placenta as well as the development of cellular lineages such as those derived from the mesoderm and ectoderm.[11]

References

  1. GRCh38: Ensembl release 89: ENSG00000185559 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Laborda J, Sausville EA, Hoffman T, Notario V (1993). "dlk, a Putative Mammalian Homeotic Gene Differentially Expressed in Small Cell Lung Carcinoma and Neuroendocrine Tumor Cell Line". The Journal of Biological Chemistry. 268 (6): 3817–20. PMID 8095043.
  5. Jensen CH, Krogh TN, Højrup P, Clausen PP, Skjødt K, Larsson LI, Enghild JJ, Teisner B (1994). "Protein Structure of Fetal Antigen 1 (FA1). A Novel Circulating Human Epidermal-Growth-Factor-Like Protein Expressed in Neuroendocrine Tumors and its Relation to the Gene Products of Dlk and pG2". European Journal of Biochemistry. 225 (1): 83–92. doi:10.1111/j.1432-1033.1994.00083.x. PMID 7925474.
  6. EntrezGene 8788
  7. Wang Y, Sul HS (2009). "Pref-1 Regulates Mesenchymal Cell Commitment and Differentiation through Sox9". Cell Metabolism. 9 (3): 287–302. doi:10.1016/j.cmet.2009.01.013. PMC 2673480. PMID 19254573.
  8. Adipogenesis at the US National Library of Medicine Medical Subject Headings (MeSH)
  9. Laborda J (2000). "The role of the epidermal growth factor-like protein dlk in cell differentiation". Histology and Histopathology. 15 (1): 119–29. PMID 10668203.
  10. Lin SP, Coan P, da Rocha ST, Seitz H, Cavaille J, Teng PW, Takada S, Ferguson-Smith AC (Jan 2007). "Differential regulation of imprinting in the murine embryo and placenta by the Dlk1-Dio3 imprinting control region". Development. 134 (2): 417–426. doi:10.1242/dev.02726. PMID 17166925.
  11. Hernandez A, Fiering S, Martinez E, Galton VA, St Germain D (Nov 2002). "The gene locus encoding iodothyronine deiodinase type 3 (Dio3) is imprinted in the fetus and expresses antisense transcripts". Endocrinology. 143 (11): 4483–4486. doi:10.1210/en.2002-220800. PMID 12399446.

Further reading


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