DDX41

Probable ATP-dependent RNA helicase DDX41 is an enzyme that in humans is encoded by the DDX41 gene.[5][6]

DDX41
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P6N
Identifiers
Aliases	DDX41, ABS, MPLPF, DEAD-box helicase 41
External IDs	OMIM: 608170 MGI: 1920185 HomoloGene: 9431 GeneCards: DDX41
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.3 Start 177,511,577 bp[1] End 177,516,961 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B1 Start 55,530,410 bp[2] End 55,536,658 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • nucleotide binding • GO:0008026 helicase activity • metal ion binding • GO:0001948 protein binding • nucleic acid binding • hydrolase activity • ATP binding • RNA binding Cellular component • cytosol • catalytic step 2 spliceosome • membrane • endoplasmic reticulum • cell nucleus • spliceosomal complex • nucleolus • cytoplasm Biological process • cellular response to interferon-beta • mRNA processing • regulation of type I interferon production • defense response to virus • RNA secondary structure unwinding • RNA splicing • positive regulation of type I interferon production • positive regulation of transcription from RNA polymerase II promoter • apoptotic process • mRNA splicing, via spliceosome • cellular proliferation • cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51428	72935
Ensembl	ENSG00000183258	ENSMUSG00000021494
UniProt	Q9UJV9	Q91VN6
RefSeq (mRNA)	NM_016222 NM_001321732 NM_001321830	NM_134059
RefSeq (protein)	NP_001308661 NP_001308759 NP_057306	NP_598820
Location (UCSC)	Chr 5: 177.51 – 177.52 Mb	Chr 13: 55.53 – 55.54 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000183258 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021494 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Irion U, Leptin M (Feb 2000). "Developmental and cell biological functions of the Drosophila DEAD-box protein abstrakt". Curr Biol. 9 (23): 1373–81. doi:10.1016/S0960-9822(00)80082-2. PMID 10607561. S2CID 16448276.
6. "Entrez Gene: DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Abdul-Ghani M, Hartman KL, Ngsee JK (2005). "Abstrakt Interacts With and Regulates the Expression of Sorting Nexin-2". J. Cell. Physiol. 204 (1): 210–8. doi:10.1002/jcp.20285. PMC 2963638. PMID 15690390.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.