D-inositol-3-phosphate glycosyltransferase
D-inositol-3-phosphate glycosyltransferase (EC 2.4.1.250, mycothiol glycosyltransferases, MshA) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:1D-myo-inositol 3-phosphate alpha-D-glycosyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP
| D-inositol-3-phosphate glycosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.250 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme catalyses the first dedicated reaction in the biosynthesis of mycothiol.
References
- Newton GL, Koledin T, Gorovitz B, Rawat M, Fahey RC, Av-Gay Y (June 2003). "The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA)". Journal of Bacteriology. 185 (11): 3476–9. doi:10.1128/JB.185.11.3476-3479.2003. PMC 155378. PMID 12754249.
- Newton GL, Ta P, Bzymek KP, Fahey RC (November 2006). "Biochemistry of the initial steps of mycothiol biosynthesis". The Journal of Biological Chemistry. 281 (45): 33910–20. doi:10.1074/jbc.M604724200. PMID 16940050.
- Vetting MW, Frantom PA, Blanchard JS (June 2008). "Structural and enzymatic analysis of MshA from Corynebacterium glutamicum: substrate-assisted catalysis". The Journal of Biological Chemistry. 283 (23): 15834–44. doi:10.1074/jbc.M801017200. PMC 2414306. PMID 18390549.
External links
- D-inositol-3-phosphate+glycosyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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