Cytoplasm-to-vacuole targeting

Cytoplasm-to-vacuole targeting (Cvt) is an autophagy-related pathway in yeast. Under vegetative conditions it delivers hydrolases, such as aminopeptidase 1 (Ape1), to the vacuole.[1][2] This makes the cvt pathway the only known biosynthetic pathway to utilize the machinery of autophagy for operation.[1]

Nomenclature

The abbreviation Cvt comes from the emphasis Cytoplasm vacuole targeting, not from Cytoplasm-to-vacuole targeting.

References

Lynch-Day MA, Klionsky DJ (2010). "The Cvt pathway as a model for selective autophagy" (PDF). FEBS Letters. 584 (7): 1359–66. doi:10.1016/j.febslet.2010.02.013. hdl:2027.42/116339. PMC 2843786. PMID 20146925.
Klionsky, Daniel J. (2005-01-01). "The molecular machinery of autophagy: unanswered questions". J Cell Sci. 118 (1): 7–18. doi:10.1242/jcs.01620. ISSN 0021-9533. PMC 1828869. PMID 15615779.

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[pmid20146925-1] Lynch-Day MA, Klionsky DJ (2010). "The Cvt pathway as a model for selective autophagy" (PDF). FEBS Letters. 584 (7): 1359–66. doi:10.1016/j.febslet.2010.02.013. hdl:2027.42/116339. PMC 2843786. PMID 20146925.

[2] Klionsky, Daniel J. (2005-01-01). "The molecular machinery of autophagy: unanswered questions". J Cell Sci. 118 (1): 7–18. doi:10.1242/jcs.01620. ISSN 0021-9533. PMC 1828869. PMID 15615779.