Cynthia Larive

Cynthia Larive is an American scientist and academic administrator serving as the Chancellor of University of California, Santa Cruz. Larive's research focuses on nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry. She was previously a professor of chemistry and Provost and Executive Vice Chancellor at the University of California, Riverside. She is a fellow of AAAS, IUPAC and ACS, Associate Editor for the ACS journal Analytical Chemistry and editor of the Analytical Sciences Digital Library.

Cynthia Larive
11th Chancellor of the University of California, Santa Cruz
Incumbent
Assumed office July 1, 2019
Preceded by	George Blumenthal
Alma mater	South Dakota State University (BS) Purdue University (MS) University of California, Riverside (PhD)
Scientific career
Fields	Bioanalytical chemistry
Institutions	University of Kansas University of California, Riverside University of California, Santa Cruz
Thesis	NMR studies of neurohypophyseal peptide hormones (1992)
Doctoral advisor	Dallas L. Rabenstein

Education

Larive received her bachelor of science from South Dakota State University in 1980, and her Masters of Science degree from Purdue University in 1982. In 1992, she was awarded a Ph.D. in Chemistry from the University of California, Riverside after working under the direction of Dallas L. Rabenstein.[1][2][3]

Career

Larive began her career as a professor in the chemistry department at the University of Kansas, and later joined the faculty of the University of California, Riverside, in 2005.[2] Since 2004 she has served as the editor-in-chief of the Analytical Sciences Digital Library.[4]

In February 2017, Larive was appointed interim provost and executive vice chancellor for University of California, Riverside, and the appointment was made permanent in October.[5]

On May 16, 2019, Larive was announced as the new Chancellor of University of California, Santa Cruz, succeeding George Blumenthal[6] effective July 1.[7]

Research

Larive worked in the field of bioanalytical chemistry, applying analytical tools such as nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry to the products of chemical separations. Much of her research focused on reducing the amount of sample needed for analysis, such as constructing microcoil NMR probes that can measure as little as 25 nL of sample and are usable as part of an capillary isotachophoresis apparatus. This has been applied to structure determination of heparin and heparan sulfate.[1][8] She developed NMR pulse sequences to study protein ligand interactions in complexes with multiple ligands.[1][9] She also researches analytical methods for metabolomics[1][10] and chemogenomics for the reaction of plants to pesticides and hypoxia using NMR and mass spectroscopy.[1]

NMR is often thought of as a low-sensitivity method, but Larive's laboratory has developed ways of increasing the sensitivity of their measurements to obtain precise chemical and structural information.[11] The techniques she has developed are relevant to understanding carbohydrate structure and biosynthesis, designing new drugs and measuring the purity of pharmaceuticals.[12] Her work in developing chemical profiles for substances also has relevance for the authentication of foodstuffs such as wine, olive oil, and pomegranate juice.[13]

Awards

Larive has received a number of awards, including the National Science Foundation CAREER Award in 1995.[14] She received the American Chemical Society Analytical Division's J. Calvin Giddings Award for Excellence in Education in 2007[15] and served as chair of the Analytical Division in 2013. In 2015, Larive received the Award for Volunteer Service to the American Chemical Society.[4] In 2018, the Analytical Chemistry Division of the American Chemical Society honored Larive with the Award for Distinguished Service to the Field of Analytical Chemistry.

Larive is a Fellow of the American Association for the Advancement of Science (AAAS) (2008),[16] the International Union of Pure and Applied Chemistry (IUPAC) (2004) and the American Chemical Society (ACS) (2011).[17]

References

1. "Department of Chemistry: Faculty". chem.ucr.edu. Retrieved 2016-03-20.
2. Nemeh, Katherine H. (2008). American Men & Women of Science. Farmington Hills, MI: Gale, Cengage Learning. p. 690. ISSN 0000-1287. OCLC 231724858.
3. Larive, Cynthia K. (1992). NMR studies of neurohypophyseal peptide hormones (Ph.D.). University of California, Riverside. OCLC 28833337. ProQuest 303984253.
4. Ainsworth, Susan J. "Volunteer Service Award To Cynthia Larive". Chemical & Engineering News. Retrieved 2016-03-20.
5. Warren, J.D. (October 24, 2017). "Cynthia K. Larive Named as UCR Provost". UCR Today.
6. "Introducing Cynthia K. Larive, UC Santa Cruz chancellor-designate". youtube.com. May 16, 2019.
7. "UC Riverside Provost Cynthia K. Larive to become UC Santa Cruz's 11th chancellor". University of California Office of the President (Press release). May 16, 2019.
8. Korir, AK; Larive, CK (August 2007). "On-line NMR detection of microgram quantities of heparin-derived oligosaccharides and their structure elucidation by microcoil NMR". Analytical and Bioanalytical Chemistry. 388 (8): 1707–16. doi:10.1007/s00216-007-1400-2. PMID 17607565. S2CID 42045793.
9. Otto, WH; Larive, CK (December 2001). "Improved spin-echo-edited NMR diffusion measurements". Journal of Magnetic Resonance. 153 (2): 273–6. Bibcode:2001JMagR.153..273O. doi:10.1006/jmre.2001.2444. PMID 11740906.
10. Larive, Cynthia K.; Barding, Gregory A.; Dinges, Meredith M. (6 January 2015). "NMR Spectroscopy for Metabolomics and Metabolic Profiling". Analytical Chemistry. 87 (1): 133–146. doi:10.1021/ac504075g. PMID 25375201.
11. Yan, Bing, ed. (2004). Analysis and purification methods in combinatorial chemistry. Hoboken (N.J.): Wiley-Interscience. p. 3. ISBN 978-0-471-26929-8. OCLC 54360519.
12. "Award Abstract #1213845 Enhancing the NMR Characterization of Amino Sugars". National Science Foundation. Archived from the original on 2 April 2016. Retrieved 21 March 2016.
13. "Chemist Tests Pomegranate Juice Authenticity". Food Quality and Safety. December 30, 2010. Retrieved 21 March 2016.
14. "IV. Accomplishments, Breakthroughs". EPSCoR Newsletter. 1 (2). 1995. Archived from the original on April 13, 2013. Retrieved 21 March 2016.
15. "UCR Chemist Recognized by the American Chemical Society". UCR News. April 10, 2007. Retrieved 21 March 2016.
16. "Thirteen UCR Faculty Members Recognized by the American Association for the Advancement of Science". University of California, Riverside. December 18, 2008. Retrieved 21 March 2016.
17. "Cindy Larive receives Award for Volunteer Service to the American Chemical Society" (PDF). ACS - DAC Division Newsletter. February 2, 2016. p. 7. Retrieved 21 March 2016.