Crc (protein)

The Catabolite repression control (Crc) protein participates in suppressing expression of several genes involved in utilization of carbon sources in Pseudomonas bacteria. [2]Presence of organic acids triggers activation of Crc and in conjunction with the Hfq protein genes that metabolize a given carbon source are downregulated until another more favorable carbon source is depleted.[3] Crc-mediated regulation impact processes such as biofilm formation,[4] virulence [5] and antibiotic susceptibility.[6]

Crc
Crystal structure of Crc in Pseudomonas aeruginosa.[1]
Identifiers
SymbolCrc
PfamPF03372
CDDcd08372

Interactions
A consensus sequence targeted by Crc mediated regulation

Hfq and Crc bind to A-rich sequences in the ribosome binding sites of genes that code for carbon utilization enzymes and consequently suppress their translation.[7]

References
  1. Wei Y, Zhang H, Gao ZQ, Xu JH, Liu QS, Dong YH (January 2013). "Structure analysis of the global metabolic regulator Crc from Pseudomonas aeruginosa". IUBMB Life. 65 (1): 50–7. doi:10.1002/iub.1103. PMID 23281037.
  2. Ramos, Juan-Luis (2004-06-17). Virulence and Gene Regulation. Springer Science & Business Media. ISBN 978-0-306-48376-9.
  3. Sonnleitner E, Bläsi U (June 2014). "Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa carbon catabolite repression". PLOS Genetics. 10 (6): e1004440. doi:10.1371/journal.pgen.1004440. PMC 4063720. PMID 24945892.
  4. O'Toole, GA; Gibbs, KA; Hager, PW; Phibbs, PV jr; Kolter, R (2000). "The global carbon metabolism regulator Crc is a component of a signal transduction pathway required for biofilm development by Pseudomonas aeruginosa". J Bacteriol. 182 (2): 425–431. doi:10.1128/jb.182.2.425-431.2000. PMC 94292. PMID 10629189.
  5. Zhang L, Chiang WC, Gao Q, Givskov M, Tolker-Nielsen T, Yang L, Zhang G (December 2012). "The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms". Microbiology. 158 (Pt 12): 3014–9. doi:10.1099/mic.0.061192-0. PMID 23023972.
  6. Yeung AT, Bains M, Hancock RE (February 2011). "The sensor kinase CbrA is a global regulator that modulates metabolism, virulence, and antibiotic resistance in Pseudomonas aeruginosa". Journal of Bacteriology. 193 (4): 918–31. doi:10.1128/jb.00911-10. PMC 3028677. PMID 21169488.
  7. Sonnleitner E, Bläsi U (June 2014). "Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa carbon catabolite repression". PLOS Genetics. 10 (6): e1004440. doi:10.1371/journal.pgen.1004440. PMC 4063720. PMID 24945892.
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